Montene
Generic Name
Montelukast
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| montene 5 mg tablet | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Montelukast is a leukotriene receptor antagonist used for the prevention and long-term treatment of asthma, relief of symptoms of seasonal and perennial allergic rhinitis, and prevention of exercise-induced bronchoconstriction.
Uses & Indications
Dosage
Adults
For asthma and seasonal allergic rhinitis: Typically 10 mg once daily in the evening. This 5 mg tablet is generally for children 6-14 years, or specific adult titration under medical supervision.
Elderly
No dosage adjustment necessary.
Renal_impairment
No dosage adjustment necessary.
How to Take
Take orally once daily in the evening, with or without food. For asthma, it should be taken in the evening. For allergic rhinitis, the time of administration may be individualized.
Mechanism of Action
Montelukast selectively antagonizes the CysLT1 receptor, preventing the actions of leukotriene D4 (LTD4) and other cysteinyl leukotrienes. This inhibition reduces bronchoconstriction, inflammation, and mucus secretion in the airways.
Pharmacokinetics
Onset
Clinical improvement generally seen within 1 day for asthma; for allergic rhinitis, symptoms improve within a few days.
Excretion
Primarily excreted in the feces via bile (approximately 86%); less than 0.2% is excreted in the urine.
Half life
Approximately 2.7 to 5.5 hours in healthy young adults.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are achieved in approximately 2-4 hours for adults.
Metabolism
Extensively metabolized in the liver, primarily by CYP3A4 and CYP2C9, and to a lesser extent by CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
Drug Interactions
Rifampin
May decrease Montelukast plasma concentration.
Phenobarbital
May decrease Montelukast plasma concentration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, typical symptoms include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Montelukast is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Montelukast or any component of the formulation.
Drug Interactions
Rifampin
May decrease Montelukast plasma concentration.
Phenobarbital
May decrease Montelukast plasma concentration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In cases of overdose, typical symptoms include abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. Treatment is symptomatic and supportive. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Montelukast is excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (patent expired)
Clinical Trials
Montelukast has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of asthma, allergic rhinitis, and exercise-induced bronchoconstriction across various age groups.
Lab Monitoring
- No routine lab monitoring is generally required. Liver function tests may be considered if hepatic dysfunction is suspected.
Doctor Notes
- Emphasize that Montelukast is for long-term control and not for acute relief.
- Educate patients and caregivers about potential neuropsychiatric side effects and to report them immediately.
- Review patient compliance and adherence to treatment plan.
Patient Guidelines
- Do not use Montelukast for sudden asthma attacks; use a rapid-acting inhaled bronchodilator for rescue.
- Continue taking Montelukast regularly, even if you feel well or your asthma symptoms improve.
- Inform your doctor immediately if you experience any mood changes, aggression, or suicidal thoughts.
- Montelukast is not a substitute for inhaled corticosteroids or other asthma medications unless advised by your doctor.
Missed Dose Advice
If a dose is missed, take the next dose at the regularly scheduled time. Do not take an extra dose to make up for a missed dose.
Driving Precautions
May cause dizziness or drowsiness in some individuals. Patients should be advised to ascertain their reaction to Montelukast before driving or operating machinery.
Lifestyle Advice
- Avoid known asthma or allergy triggers.
- Maintain a healthy lifestyle with regular exercise (if appropriate) and a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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