Mox
Generic Name
Amoxicillin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| mox 500 mg capsule | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Mox 500 mg capsule contains Amoxicillin, a penicillin antibiotic used to treat a wide range of bacterial infections. It works by preventing the growth of bacteria.
Uses & Indications
Dosage
Adults
General dosage: 250 mg to 500 mg every 8 hours, or 500 mg to 875 mg every 12 hours, depending on the severity and type of infection. Maximum dose typically 4g/day.
Elderly
Similar to adult dosage, but caution and dose adjustment may be required in cases of renal impairment.
Renal_impairment
Dosage adjustment is necessary based on creatinine clearance. For CrCl < 30 mL/min, dose reduction or increased dosing interval is typically recommended.
How to Take
Take orally, with or without food. It is crucial to complete the entire prescribed course of treatment, even if symptoms improve, to prevent antibiotic resistance and ensure full recovery.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 30 minutes to 1 hour (for antibacterial effect).
Excretion
Primarily excreted unchanged by the kidneys via tubular secretion and glomerular filtration.
Half life
1-1.5 hours in adults with normal renal function.
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Bioavailability is approximately 70-90%. Absorption is not significantly affected by food.
Metabolism
Partially metabolized (about 10-25%) to inactive penicilloic acid.
Side Effects
Contraindications
- Known hypersensitivity to amoxicillin or any other penicillin antibiotic.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., cephalosporins, carbapenems).
Drug Interactions
Warfarin
May enhance the anticoagulant effect; INR monitoring is recommended.
Probenecid
Increases and prolongs amoxicillin blood levels by decreasing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity by reducing its renal clearance.
Oral Contraceptives
May rarely reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal upset (nausea, vomiting, diarrhea), fluid and electrolyte imbalance. In rare cases, crystalluria leading to renal failure has been reported. Treatment is symptomatic and supportive. Hemodialysis can remove amoxicillin from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe for use during pregnancy, but should be used only if clearly needed. Amoxicillin is excreted in breast milk in small quantities; generally considered compatible with breastfeeding, but monitor the infant for potential adverse effects like diarrhea, rash, or fungal infections.
Side Effects
Contraindications
- Known hypersensitivity to amoxicillin or any other penicillin antibiotic.
- History of severe hypersensitivity reaction to any other beta-lactam antibacterial agent (e.g., cephalosporins, carbapenems).
Drug Interactions
Warfarin
May enhance the anticoagulant effect; INR monitoring is recommended.
Probenecid
Increases and prolongs amoxicillin blood levels by decreasing renal tubular secretion.
Methotrexate
May increase methotrexate toxicity by reducing its renal clearance.
Oral Contraceptives
May rarely reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include gastrointestinal upset (nausea, vomiting, diarrhea), fluid and electrolyte imbalance. In rare cases, crystalluria leading to renal failure has been reported. Treatment is symptomatic and supportive. Hemodialysis can remove amoxicillin from the circulation.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe for use during pregnancy, but should be used only if clearly needed. Amoxicillin is excreted in breast milk in small quantities; generally considered compatible with breastfeeding, but monitor the infant for potential adverse effects like diarrhea, rash, or fungal infections.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 24 to 36 months from the date of manufacture, depending on the specific manufacturer.
Availability
Available in pharmacies and hospitals.
Approval Status
Approved globally by major regulatory bodies, including FDA and DGDA.
Patent Status
Expired, widely available as generic.
WHO Essential Medicine
YesClinical Trials
Amoxicillin has undergone extensive clinical trials since its development, establishing its efficacy and safety for a broad range of bacterial infections. Ongoing research may involve new formulations or resistance patterns.
Lab Monitoring
- Renal function tests (for prolonged therapy or in patients with renal impairment).
- Liver function tests (for prolonged use).
- Complete Blood Count (CBC) (for prolonged use).
Doctor Notes
- Emphasize to patients the importance of completing the full antibiotic course to prevent bacterial resistance.
- Educate patients on potential allergic reactions, especially those with a history of penicillin allergy.
- Consider dose adjustments for elderly patients and those with impaired renal function.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not skip doses or stop taking the medicine early, even if you feel better, to prevent antibiotic resistance.
- Drink plenty of fluids while on this medication.
- Inform your doctor if you experience any unusual or severe side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Amoxicillin generally does not impair the ability to drive or operate machinery. However, if you experience side effects such as dizziness, confusion, or severe allergic reactions, avoid these activities.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection.
- Ensure proper hydration.
- Avoid sharing antibiotics with others.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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