Moxacil
Generic Name
Amoxicillin 500 mg capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxacil 500 mg capsule | ৳ 7.50 | ৳ 75.00 |
Description
Overview of the medicine
Moxacil 500 mg capsule is a broad-spectrum antibiotic containing Amoxicillin, used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
250 mg to 500 mg every 8 hours, or 750 mg to 1 g every 12 hours, depending on the severity and type of infection.
Elderly
Similar to adult dosage, but renal function should be considered.
Renal_impairment
Dosage adjustment is necessary for patients with severe renal impairment (CrCl < 30 mL/min).
How to Take
Moxacil 500 mg capsule should be swallowed whole with water, with or without food. Taking it with food may reduce gastrointestinal discomfort.
Mechanism of Action
Amoxicillin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) in the bacterial cell wall, leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Primarily excreted unchanged by the kidneys (glomerular filtration and tubular secretion) into the urine.
Half life
1-1.5 hours (in individuals with normal renal function)
Absorption
Rapidly and well absorbed from the gastrointestinal tract, especially when taken on an empty stomach. Peak plasma concentrations are achieved in about 1-2 hours.
Metabolism
Limited hepatic metabolism; about 10-25% of the dose is metabolized to inactive penicilloic acid.
Side Effects
Contraindications
- Known hypersensitivity to penicillin or any component of the formulation
- History of severe allergic reaction to other beta-lactam antibiotics (e.g., cephalosporins, carbapenems)
Drug Interactions
Warfarin
May prolong prothrombin time (INR); careful monitoring is required.
Probenecid
Decreases renal tubular secretion of amoxicillin, leading to increased and prolonged plasma levels.
Methotrexate
Amoxicillin may reduce methotrexate excretion, increasing its toxicity.
Oral contraceptives
May reduce the efficacy of oral contraceptives (rarely significant, but advise additional contraception).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset (nausea, vomiting, diarrhea), fluid and electrolyte imbalance. In cases of massive overdose, renal failure and convulsions have been reported. Treatment is symptomatic and supportive; hemodialysis may be used to remove amoxicillin from circulation.
Pregnancy & Lactation
Category B. Generally considered safe during pregnancy, but should be used with caution. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential adverse effects (e.g., diarrhea, candidiasis).
Side Effects
Contraindications
- Known hypersensitivity to penicillin or any component of the formulation
- History of severe allergic reaction to other beta-lactam antibiotics (e.g., cephalosporins, carbapenems)
Drug Interactions
Warfarin
May prolong prothrombin time (INR); careful monitoring is required.
Probenecid
Decreases renal tubular secretion of amoxicillin, leading to increased and prolonged plasma levels.
Methotrexate
Amoxicillin may reduce methotrexate excretion, increasing its toxicity.
Oral contraceptives
May reduce the efficacy of oral contraceptives (rarely significant, but advise additional contraception).
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset (nausea, vomiting, diarrhea), fluid and electrolyte imbalance. In cases of massive overdose, renal failure and convulsions have been reported. Treatment is symptomatic and supportive; hemodialysis may be used to remove amoxicillin from circulation.
Pregnancy & Lactation
Category B. Generally considered safe during pregnancy, but should be used with caution. Excreted in breast milk in small amounts; generally considered compatible with breastfeeding, but monitor infant for potential adverse effects (e.g., diarrhea, candidiasis).
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic (patent expired)
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used for decades. Numerous clinical trials have established its efficacy and safety for various bacterial infections.
Lab Monitoring
- Renal function tests (for prolonged therapy or in renal impairment)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Advise patients to complete the entire course of treatment.
- Be aware of potential hypersensitivity reactions, especially in patients with a history of penicillin allergy.
- Consider renal function adjustment in elderly or renally impaired patients.
Patient Guidelines
- Take the full course of medication as prescribed, even if symptoms improve.
- Do not share this medication with others.
- Contact your doctor if symptoms worsen or do not improve.
- Report any severe allergic reactions immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
Generally, Moxacil 500 mg capsule does not affect the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated, especially if experiencing diarrhea.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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