Moxaclav
Generic Name
Amoxicillin and Clavulanic Acid
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxaclav 125 mg suspension | ৳ 220.00 | N/A |
Description
Overview of the medicine
Moxaclav 125 mg Suspension is an antibiotic combination containing Amoxicillin and Clavulanic Acid, used to treat a wide range of bacterial infections. Amoxicillin is a penicillin-type antibiotic that fights bacteria, while Clavulanic Acid prevents bacteria from destroying Amoxicillin.
Uses & Indications
Dosage
Adults
Not typically recommended for adults in this strength; higher strengths usually prescribed. Refer to product leaflet for specific adult dosages for other forms.
Elderly
Not typically recommended for elderly in this strength; higher strengths usually prescribed. Dosage adjustment may be required based on renal function.
Renal_impairment
Dosage adjustment required. For children with creatinine clearance >30 mL/min, no adjustment. For 10-30 mL/min, 125 mg/31.25 mg every 12 hours. For <10 mL/min, 125 mg/31.25 mg every 24 hours. Hemodialysis: 125 mg/31.25 mg once daily, plus an additional dose during and at the end of dialysis.
How to Take
Oral suspension. Shake the bottle well before each use. Take with food to minimize potential gastrointestinal intolerance. Complete the full course of treatment as prescribed, even if symptoms improve.
Mechanism of Action
Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis. Clavulanic Acid is a beta-lactamase inhibitor that inactivates a wide range of beta-lactamase enzymes produced by bacteria, thereby protecting Amoxicillin from degradation and extending its antibacterial spectrum.
Pharmacokinetics
Onset
Antibacterial effect typically observed within 30-60 minutes.
Excretion
Primarily excreted unchanged in the urine by glomerular filtration and tubular secretion (amoxicillin) and via renal and non-renal mechanisms (clavulanic acid).
Half life
Amoxicillin: Approximately 1-1.5 hours. Clavulanic Acid: Approximately 1 hour.
Absorption
Both amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are reached approximately 1-2 hours after dosing.
Metabolism
Amoxicillin is minimally metabolized; clavulanic acid is extensively metabolized.
Side Effects
Contraindications
- History of severe hypersensitivity reaction to beta-lactams (e.g., anaphylaxis to penicillin or cephalosporin)
- History of amoxicillin/clavulanic acid-associated jaundice or hepatic dysfunction
Drug Interactions
Probenecid
Increases amoxicillin blood levels and prolongs its effect.
Methotrexate
Increases methotrexate toxicity.
Oral contraceptives
May reduce the effectiveness of oral contraceptives.
Warfarin and other oral anticoagulants
May prolong prothrombin time; monitor INR closely.
Storage
Store dry powder below 25°C in a dry place, away from direct sunlight. Once reconstituted, store in a refrigerator (2-8°C) and discard any unused portion after 7-10 days.
Overdose
Overdose symptoms include gastrointestinal discomfort (abdominal pain, vomiting, diarrhea), rash, or hyperkinesis. Treatment is symptomatic and supportive. Hemodialysis can remove amoxicillin and clavulanic acid from the circulation.
Pregnancy & Lactation
Category B in pregnancy. Use with caution. Small amounts of both amoxicillin and clavulanic acid are excreted into breast milk. Generally considered safe, but monitor for potential adverse effects in the infant (e.g., diarrhea, candidiasis). Consult a doctor.
Side Effects
Contraindications
- History of severe hypersensitivity reaction to beta-lactams (e.g., anaphylaxis to penicillin or cephalosporin)
- History of amoxicillin/clavulanic acid-associated jaundice or hepatic dysfunction
Drug Interactions
Probenecid
Increases amoxicillin blood levels and prolongs its effect.
Methotrexate
Increases methotrexate toxicity.
Oral contraceptives
May reduce the effectiveness of oral contraceptives.
Warfarin and other oral anticoagulants
May prolong prothrombin time; monitor INR closely.
Storage
Store dry powder below 25°C in a dry place, away from direct sunlight. Once reconstituted, store in a refrigerator (2-8°C) and discard any unused portion after 7-10 days.
Overdose
Overdose symptoms include gastrointestinal discomfort (abdominal pain, vomiting, diarrhea), rash, or hyperkinesis. Treatment is symptomatic and supportive. Hemodialysis can remove amoxicillin and clavulanic acid from the circulation.
Pregnancy & Lactation
Category B in pregnancy. Use with caution. Small amounts of both amoxicillin and clavulanic acid are excreted into breast milk. Generally considered safe, but monitor for potential adverse effects in the infant (e.g., diarrhea, candidiasis). Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: Typically 2-3 years. Reconstituted suspension: 7-10 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, hospitals
Approval Status
Approved by health authorities worldwide (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials establishing its efficacy and safety for various bacterial infections. Ongoing research focuses on resistance patterns and new formulations.
Lab Monitoring
- Liver function tests (especially in patients with pre-existing hepatic impairment)
- Renal function tests (for prolonged therapy or in patients with renal impairment)
- Complete blood count (for prolonged therapy)
Doctor Notes
- Emphasize adherence to the full prescribed course.
- Advise patients on proper reconstitution and storage of the suspension.
- Caution about potential for allergic reactions, including delayed hypersensitivity reactions.
Patient Guidelines
- Always complete the full course of antibiotics as prescribed by your doctor, even if you feel better.
- Shake the suspension bottle well before each use.
- Measure the dose accurately using the provided measuring spoon or cup.
- Report any severe or persistent side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose to catch up.
Driving Precautions
Generally, Moxaclav 125 mg Suspension does not impair the ability to drive or operate machinery. However, if side effects like dizziness or headache occur, avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Ensure proper hygiene to prevent reinfection.
- Avoid self-medication with antibiotics.
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