Moxquin
Generic Name
Moxifloxacin 0.5% Intraocular Injection
Manufacturer
Generic Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxquin 05 intraocular injection | ৳ 150.00 | N/A |
Description
Overview of the medicine
Moxquin-05-Intraocular-Injection is a sterile, preservative-free solution of moxifloxacin 0.5% used intracamerally during cataract surgery to reduce the risk of postoperative endophthalmitis.
Uses & Indications
Dosage
Adults
Typically, 0.5 mL of a 0.5% moxifloxacin solution (250 mcg) administered intracamerally at the end of cataract surgery.
Elderly
No specific dosage adjustment required for elderly patients.
Renal_impairment
No dosage adjustment necessary due to minimal systemic absorption.
How to Take
Administered by a qualified ophthalmologist as a single intracamerally injection into the anterior chamber of the eye at the conclusion of ocular surgery.
Mechanism of Action
Moxifloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to bactericidal activity.
Pharmacokinetics
Onset
Rapid local antibacterial effect within minutes of administration.
Excretion
Excreted primarily through ocular elimination pathways and minimal systemic excretion.
Half life
Aqueous humor half-life is short, typically in hours, but local therapeutic levels are maintained.
Absorption
Minimal systemic absorption after intraocular administration. High concentrations are rapidly achieved in the aqueous humor and vitreous.
Metabolism
Primarily local action, negligible systemic metabolism for intraocular use.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones, or any component of the formulation.
- Use in patients with a history of allergic reactions to fluoroquinolones.
Drug Interactions
Systemic Drug Interactions
Due to minimal systemic absorption, clinically significant drug-drug interactions are unlikely with intraocular administration.
Storage
Store at controlled room temperature (20-25°C), protect from light. Do not freeze. Discard any unused portion.
Overdose
Overdose is unlikely with controlled intraocular administration by a professional. If accidental overdose occurs, management is supportive and symptomatic.
Pregnancy & Lactation
Use with caution. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. Minimal systemic absorption reduces risk, but consult a physician.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolones, or any component of the formulation.
- Use in patients with a history of allergic reactions to fluoroquinolones.
Drug Interactions
Systemic Drug Interactions
Due to minimal systemic absorption, clinically significant drug-drug interactions are unlikely with intraocular administration.
Storage
Store at controlled room temperature (20-25°C), protect from light. Do not freeze. Discard any unused portion.
Overdose
Overdose is unlikely with controlled intraocular administration by a professional. If accidental overdose occurs, management is supportive and symptomatic.
Pregnancy & Lactation
Use with caution. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. Minimal systemic absorption reduces risk, but consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months when stored under recommended conditions.
Availability
Hospitals, Ophthalmic Surgery Centers, Specialty Pharmacies
Approval Status
Approved by regulatory authorities for ophthalmic use
Patent Status
Generic formulations available, specific intraocular formulation may have formulation-specific patents or be generic.
Clinical Trials
Extensive clinical trials support the efficacy and safety of intracameral moxifloxacin for endophthalmitis prophylaxis.
Lab Monitoring
- Not typically required for single intraocular administration.
Doctor Notes
- Ensure aseptic technique during preparation and administration to prevent contamination.
- Confirm drug concentration and volume before injection. This formulation is preservative-free.
- Monitor for signs of increased intraocular pressure post-injection.
Patient Guidelines
- This medication is administered by a healthcare professional during eye surgery.
- Report any unusual eye pain, redness, or vision changes after surgery.
- Follow all postoperative instructions provided by your ophthalmologist carefully.
Missed Dose Advice
Not applicable as this is a single dose administered by a medical professional during surgery.
Driving Precautions
Temporary blurred vision may occur after surgery. Do not drive or operate machinery until vision is clear and stable.
Lifestyle Advice
- Avoid rubbing the eye after surgery.
- Protect the eye as instructed by the doctor.
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