Moxquin
Generic Name
Moxquin-400-mg-tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| moxquin 400 mg tablet | ৳ 40.00 | ৳ 160.00 |
Description
Overview of the medicine
Moxquin 400 mg Tablet contains Moxifloxacin, a broad-spectrum fluoroquinolone antibiotic, used to treat various bacterial infections including respiratory tract infections, skin and soft tissue infections, and intra-abdominal infections.
Uses & Indications
Dosage
Adults
400 mg once daily for 5-21 days, depending on the infection type and severity. Must complete the full course as prescribed.
Elderly
No dosage adjustment is generally required for elderly patients, but caution is advised in those with pre-existing cardiac conditions or electrolyte imbalances.
Renal_impairment
No dosage adjustment is necessary for patients with mild to severe renal impairment (including those on dialysis).
How to Take
Take the tablet orally, with or without food. Swallow whole with water, do not crush or chew. It is recommended to take it at approximately the same time each day.
Mechanism of Action
Moxifloxacin exerts its bactericidal action by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
Within hours of administration.
Excretion
Excreted in both feces (approximately 60%) and urine (approximately 40%), partially as unchanged drug and partially as metabolites.
Half life
Approximately 11-15 hours.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract; absolute bioavailability is approximately 90%. Peak plasma concentrations are reached within 0.5-4 hours.
Metabolism
Undergoes Phase II biotransformation (glucuronide and sulfate conjugation) primarily in the liver. It is not metabolized by cytochrome P450 enzymes.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolone antibiotics.
- History of QT prolongation or uncorrected hypokalemia.
- Patients with liver impairment (Child-Pugh C) or elevated transaminases.
- History of tendon disorders related to quinolone use.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.
Corticosteroids
Increased risk of tendon disorders, especially in elderly patients.
Antacids, Sucralfate, Iron/Zinc supplements, Multivitamins
These agents can chelate moxifloxacin, significantly reducing its absorption. Administer moxifloxacin at least 4 hours before or 8 hours after these products.
QT prolonging drugs (e.g., antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics)
Concomitant use may increase the risk of QT interval prolongation and arrhythmias. Avoid co-administration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic treatment and supportive measures are recommended. There is no specific antidote. ECG monitoring and blood pressure monitoring are important. Activated charcoal may be useful shortly after ingestion.
Pregnancy & Lactation
Moxifloxacin should not be used during pregnancy or lactation unless the potential benefit justifies the potential risk to the fetus or infant. Animal studies have shown adverse effects on bone and cartilage development. Excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to moxifloxacin or other quinolone antibiotics.
- History of QT prolongation or uncorrected hypokalemia.
- Patients with liver impairment (Child-Pugh C) or elevated transaminases.
- History of tendon disorders related to quinolone use.
Drug Interactions
Warfarin
May enhance the anticoagulant effect of warfarin, requiring careful monitoring of INR.
Corticosteroids
Increased risk of tendon disorders, especially in elderly patients.
Antacids, Sucralfate, Iron/Zinc supplements, Multivitamins
These agents can chelate moxifloxacin, significantly reducing its absorption. Administer moxifloxacin at least 4 hours before or 8 hours after these products.
QT prolonging drugs (e.g., antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics)
Concomitant use may increase the risk of QT interval prolongation and arrhythmias. Avoid co-administration.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic treatment and supportive measures are recommended. There is no specific antidote. ECG monitoring and blood pressure monitoring are important. Activated charcoal may be useful shortly after ingestion.
Pregnancy & Lactation
Moxifloxacin should not be used during pregnancy or lactation unless the potential benefit justifies the potential risk to the fetus or infant. Animal studies have shown adverse effects on bone and cartilage development. Excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Moxifloxacin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various bacterial infections.
Lab Monitoring
- Liver function tests (baseline and during therapy, especially in those with pre-existing liver disease)
- Renal function tests
- Electrolyte levels (potassium, magnesium) if risk for QT prolongation
- Blood glucose (especially in diabetic patients, due to risk of dysglycemia)
Doctor Notes
- Counsel patients on the black box warnings, particularly regarding tendon rupture and peripheral neuropathy, and advise immediate discontinuation if symptoms occur.
- Be aware of potential drug interactions, especially with QT prolonging agents and multivalent cations. Adjust administration schedule as needed.
- Consider alternative antibiotics in patients with myasthenia gravis or a history of aortic aneurysm/dissection due to increased risks.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Avoid excessive sun exposure and use protective clothing/sunscreen due to photosensitivity.
- Report any tendon pain, swelling, or joint stiffness immediately to your doctor.
- Inform your doctor about all other medications you are taking, including OTC drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Moxquin may cause dizziness or visual disturbances. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
- Avoid excessive caffeine intake.
- Limit strenuous physical activity that could strain tendons.
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