Napsod
Generic Name
Naproxen
Manufacturer
Reputable Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| napsod 275 mg tablet | ৳ 6.00 | ৳ 60.00 |
| napsod 550 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, fever, and inflammation. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
For mild to moderate pain, 250-500 mg twice daily. For rheumatoid arthritis, osteoarthritis, 250-500 mg twice daily.
Elderly
Lower doses recommended, monitor for adverse effects.
Renal_impairment
Reduced dosage necessary, monitor renal function.
How to Take
Orally, preferably with food or milk to reduce gastrointestinal upset.
Mechanism of Action
Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby blocking the synthesis of prostaglandins. Prostaglandins are mediators of inflammation, pain, and fever.
Pharmacokinetics
Onset
Approximately 1 hour
Excretion
Mainly excreted in the urine (about 95%) as unchanged drug and metabolites.
Half life
12-17 hours
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Primarily metabolized in the liver by the cytochrome P450 system (CYP2C9).
Side Effects
Contraindications
- •Hypersensitivity to naproxen or other NSAIDs
- •Active gastrointestinal bleeding or peptic ulcer
- •Severe renal or hepatic impairment
- •Last trimester of pregnancy
Drug Interactions
Lithium
Increased lithium levels
Warfarin
Increased risk of bleeding
Diuretics
Reduced diuretic effect
ACE inhibitors
Reduced antihypertensive effect
Storage
Store in a cool, dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain. Management includes gastric emptying and symptomatic treatment.
Pregnancy & Lactation
Avoid during the last trimester of pregnancy. Use with caution during early pregnancy and lactation, consult doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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