Take the tablet whole with water. Do not crush, chew, or split the tablet. It should be taken at least 30 minutes before a meal for optimal Esomeprazole absorption and gastric protection, though it may also be taken with or after food to minimize stomach upset from Naproxen.

Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis, thereby producing anti-inflammatory, analgesic, and antipyretic effects. Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by inhibiting the H+/K+-ATPase in gastric parietal cells, providing gastroprotection.

• •Hypersensitivity to Naproxen, Esomeprazole, or any components
• •History of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs
• •Active gastrointestinal bleeding or peptic ulcer disease
• •Severe renal or hepatic impairment
• •Last trimester of pregnancy
• •Severe heart failure

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms of Naproxen overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain, GI bleeding. Esomeprazole overdose symptoms are generally mild. Management is symptomatic and supportive. Gastric lavage and/or activated charcoal may be considered within a few hours of ingestion. Hemodialysis is generally not effective for Naproxen.

Avoid in the third trimester of pregnancy due to potential for premature closure of the fetal ductus arteriosus. Use with caution during early pregnancy and lactation only if clearly needed and the potential benefits outweigh the risks. Consult a doctor.