Natazol
Generic Name
Natamycin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| natazol 005 nasal drop | ৳ 45.00 | N/A |
| natazol 0025 nasal drop | ৳ 40.00 | N/A |
Description
Overview of the medicine
Natazol (Natamycin) is a broad-spectrum antifungal agent primarily used for topical treatment of fungal infections of the eye, including fungal keratitis, conjunctivitis, and blepharitis caused by susceptible fungi.
Uses & Indications
Dosage
Adults
For fungal keratitis, 1 drop into the affected eye(s) every 1-2 hours for 3-4 days, then 1 drop 6-8 times daily for up to 14-21 days or until resolution. Dosage may be tapered gradually.
Elderly
No specific dose adjustment is required for elderly patients.
Renal_impairment
No dose adjustment is necessary due to minimal systemic absorption.
How to Take
Shake well before use. Instill drops into the conjunctival sac. Avoid touching the dropper tip to the eye or any other surface to prevent contamination. If using other eye drops, wait at least 5-10 minutes between applications.
Mechanism of Action
Natamycin acts by binding to ergosterol, a vital component of fungal cell membranes, leading to increased permeability of the membrane. This disruption causes leakage of essential intracellular components and ultimately fungal cell death.
Pharmacokinetics
Onset
Clinical improvement may be seen within days, but full eradication takes weeks.
Excretion
Not relevant for topical ophthalmic use due to negligible systemic absorption.
Half life
Not relevant for topical ophthalmic use due to negligible systemic absorption.
Absorption
Minimal systemic absorption occurs after topical ophthalmic administration due to its poor solubility and large molecular size. Primarily acts locally on the eye surface.
Metabolism
No significant systemic metabolism due to minimal absorption.
Side Effects
Contraindications
- Hypersensitivity to Natamycin or any component of the formulation.
Drug Interactions
Other topical ophthalmic medications
Allow at least 5-10 minutes between applications of different eye drops to prevent wash-out and ensure adequate absorption.
Storage
Store at controlled room temperature (20-25°C). Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Topical ophthalmic overdose is unlikely to cause systemic toxicity due to minimal absorption. Excessive local application may lead to ocular irritation, which can be managed by rinsing the eye with sterile water.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Minimal systemic absorption suggests low risk, but caution is advised. Consult a doctor before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to Natamycin or any component of the formulation.
Drug Interactions
Other topical ophthalmic medications
Allow at least 5-10 minutes between applications of different eye drops to prevent wash-out and ensure adequate absorption.
Storage
Store at controlled room temperature (20-25°C). Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Topical ophthalmic overdose is unlikely to cause systemic toxicity due to minimal absorption. Excessive local application may lead to ocular irritation, which can be managed by rinsing the eye with sterile water.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Minimal systemic absorption suggests low risk, but caution is advised. Consult a doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months for unopened product. Discard 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Natamycin's efficacy and safety for treating fungal keratitis, especially against filamentous fungi, making it a first-line treatment option.
Lab Monitoring
- No specific lab monitoring is required for topical ophthalmic Natamycin. Clinical evaluation and fungal culture may be performed to assess treatment efficacy.
Doctor Notes
- Confirm fungal etiology before initiating treatment.
- Monitor patient response closely and adjust treatment duration as needed.
- Educate patients on proper administration technique to ensure compliance and minimize contamination.
Patient Guidelines
- Use the medication for the full prescribed duration, even if symptoms improve.
- Do not wear contact lenses during treatment for fungal eye infections.
- Report any worsening symptoms or severe irritation to your doctor immediately.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Natamycin ophthalmic solution may cause temporary blurred vision immediately after application. Patients should be advised to wait until their vision clears before driving or operating machinery.
Lifestyle Advice
- Maintain good eye hygiene.
- Avoid touching your eyes unnecessarily.
- Do not share eye drops with others.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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