Nauset
Generic Name
Ondansetron
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nauset 8 mg injection | ৳ 30.00 | N/A |
Description
Overview of the medicine
Nauset 8 mg Injection contains Ondansetron, an anti-emetic drug used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery.
Uses & Indications
Dosage
Adults
Chemotherapy-induced nausea and vomiting (CINV): Highly emetogenic: 24 mg orally once, 30 minutes before chemotherapy, or 8 mg IV/IM immediately before chemotherapy, followed by 8 mg orally twice daily for 1-2 days. Moderately emetogenic: 8 mg orally twice daily or 8 mg IV/IM once immediately before chemotherapy. Post-operative nausea and vomiting (PONV): 4 mg IV/IM as a single dose immediately before induction of anesthesia, or post-operatively if nausea/vomiting occurs.
Elderly
No dosage adjustment is generally required for patients over 65 years. However, for patients >75 years, the initial IV dose should not exceed 16 mg.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Nauset 8 mg Injection is administered intravenously (IV) or intramuscularly (IM) by a healthcare professional. It can be given as a slow IV injection over at least 30 seconds, preferably over 2-5 minutes, or as an IM injection. It may be diluted and infused over 15 minutes for some indications.
Mechanism of Action
Ondansetron is a selective serotonin 5-HT3 receptor antagonist. Serotonin 5-HT3 receptors are present both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone (CTZ). By blocking these receptors, ondansetron prevents the initiation of the vomiting reflex.
Pharmacokinetics
Onset
Within 30 minutes (IV)
Excretion
About 5% of the dose is excreted unchanged in urine; the remainder is excreted as metabolites in urine and feces.
Half life
Approximately 3-6 hours (adults); 20 hours (neonates); 8 hours (elderly)
Absorption
Rapidly and extensively absorbed after oral administration, but bioavailability is approximately 60% due to first-pass metabolism. IV administration bypasses this.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP1A2, CYP2D6, CYP3A4) via hydroxylation, followed by glucuronide or sulfate conjugation.
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine.
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol and increase the risk of serotonin syndrome.
Apomorphine
Concomitant use is contraindicated due to reports of profound hypotension and loss of consciousness.
Drugs that prolong QT interval
Use with caution due to potential additive QT prolongation effect (e.g., antiarrhythmics, antipsychotics).
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron plasma concentrations.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. ECG monitoring is recommended. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. However, human data is limited. Use during pregnancy only if clearly needed. Ondansetron is excreted in the milk of lactating rats; it is not known whether it is excreted in human milk. Exercise caution when administering to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine.
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol and increase the risk of serotonin syndrome.
Apomorphine
Concomitant use is contraindicated due to reports of profound hypotension and loss of consciousness.
Drugs that prolong QT interval
Use with caution due to potential additive QT prolongation effect (e.g., antiarrhythmics, antipsychotics).
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron plasma concentrations.
Storage
Store below 30°C. Protect from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. ECG monitoring is recommended. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. However, human data is limited. Use during pregnancy only if clearly needed. Ondansetron is excreted in the milk of lactating rats; it is not known whether it is excreted in human milk. Exercise caution when administering to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored under recommended conditions.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established ondansetron's efficacy and safety in preventing CINV, RINV, and PONV. These trials have shown it to be significantly more effective than placebo and comparable to or superior to older anti-emetics in many settings.
Lab Monitoring
- Periodic ECG monitoring in patients with underlying cardiac conditions, electrolyte abnormalities, or those taking other QT-prolonging drugs.
Doctor Notes
- Always check for potential QT prolongation risk factors before administration.
- Monitor for signs of serotonin syndrome if co-administered with serotonergic drugs.
- Ensure slow IV administration to minimize the risk of transient visual disturbances and cardiac events.
Patient Guidelines
- Inform your doctor about all your medical conditions and medications.
- Report any unusual side effects, especially difficulty breathing, rash, or changes in vision.
- Ensure proper hydration as advised by your healthcare provider.
Missed Dose Advice
As this is an injection administered by a healthcare professional, a missed dose is unlikely. If a scheduled dose is missed, inform your doctor immediately to reschedule.
Driving Precautions
Ondansetron may cause dizziness or visual disturbances. Patients should be advised not to drive or operate machinery if they experience these effects.
Lifestyle Advice
- Avoid alcohol consumption, which can worsen nausea.
- Maintain a balanced diet to aid recovery from chemotherapy or surgery.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Nauset Brand
Other medicines available under the same brand name
