Nauset
Generic Name
Ondansetron
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nauset 8 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ondansetron (Nauset) is an antiemetic medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking the action of serotonin, a natural substance in the body that can cause nausea and vomiting.
Uses & Indications
Dosage
Adults
Chemotherapy-induced nausea and vomiting (CINV): Highly emetogenic - 24 mg single dose 30 minutes before chemotherapy. Moderately emetogenic - 8 mg 30 minutes before chemotherapy, followed by 8 mg 8 and 16 hours after the first dose. Postoperative nausea and vomiting (PONV): 16 mg one hour before anesthesia, or 8 mg 1-2 hours before surgery.
Elderly
No dosage adjustment is generally required for elderly patients with normal renal and hepatic function. For patients >75 years, initial IV dose should not exceed 8 mg due to increased risk of QT prolongation.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take Nauset 8 mg tablet orally, with or without food, as directed by your doctor. For chemotherapy-induced nausea, it is usually taken 30 minutes before treatment. For postoperative nausea, it may be taken an hour before anesthesia or 1-2 hours before surgery.
Mechanism of Action
Ondansetron is a selective 5-HT3 receptor antagonist. It works by blocking serotonin from binding to 5-HT3 receptors located on the vagal afferent neurons in the gastrointestinal tract and in the chemoreceptor trigger zone (CTZ) of the central nervous system. This action prevents the initiation of the vomiting reflex.
Pharmacokinetics
Onset
Approximately 30 minutes after oral administration.
Excretion
Approximately 5% of the dose is excreted unchanged in urine, with metabolites primarily excreted via urine and feces.
Half life
Approximately 3-5 hours (adults), prolonged in hepatic impairment.
Absorption
Well absorbed from the GI tract; undergoes first-pass metabolism. Bioavailability is about 60%.
Metabolism
Extensively metabolized in the liver by cytochrome P450 enzymes (CYP1A2, CYP2D6, CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine due to the risk of profound hypotension and loss of consciousness.
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol; close monitoring is advised.
Apomorphine
Concomitant use is contraindicated due to reports of profound hypotension and loss of consciousness.
SSRIs/SNRIs
Increased risk of serotonin syndrome when used concomitantly with serotonergic drugs. Monitor for symptoms like agitation, confusion, tremor.
QT-prolonging drugs
Use with caution with other drugs known to prolong the QT interval (e.g., antiarrhythmics, antipsychotics) to avoid additive risk of cardiac arrhythmias.
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron plasma concentrations, potentially reducing efficacy.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include transient vision disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. ECG monitoring is recommended in cases of overdose. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Ondansetron should be used during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is unknown whether ondansetron is excreted in human milk; use with caution in nursing mothers or consider discontinuing breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to ondansetron or any component of the formulation.
- Concomitant use with apomorphine due to the risk of profound hypotension and loss of consciousness.
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol; close monitoring is advised.
Apomorphine
Concomitant use is contraindicated due to reports of profound hypotension and loss of consciousness.
SSRIs/SNRIs
Increased risk of serotonin syndrome when used concomitantly with serotonergic drugs. Monitor for symptoms like agitation, confusion, tremor.
QT-prolonging drugs
Use with caution with other drugs known to prolong the QT interval (e.g., antiarrhythmics, antipsychotics) to avoid additive risk of cardiac arrhythmias.
Phenytoin, Carbamazepine, Rifampicin
May decrease ondansetron plasma concentrations, potentially reducing efficacy.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include transient vision disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. ECG monitoring is recommended in cases of overdose. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Ondansetron should be used during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is unknown whether ondansetron is excreted in human milk; use with caution in nursing mothers or consider discontinuing breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, specific to batch.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of ondansetron in preventing and treating chemotherapy-induced nausea and vomiting (CINV), radiation-induced nausea and vomiting (RINV), and postoperative nausea and vomiting (PONV). These trials support its broad use in these indications.
Lab Monitoring
- ECG monitoring is recommended in patients with electrolyte abnormalities, congenital long QT syndrome, congestive heart failure, bradyarrhythmias, or those taking other QT-prolonging drugs.
- Liver function tests should be performed in patients with severe hepatic impairment.
Doctor Notes
- Advise patients on the importance of reporting any new or worsening symptoms, especially cardiac symptoms like chest pain or palpitations.
- Review concomitant medications for potential drug interactions, particularly those that prolong the QT interval or interact with CYP enzymes.
- Consider alternative antiemetics if a patient has known risk factors for Torsade de Pointes or severe hepatic impairment.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not take more or less than the recommended dose.
- Inform your doctor about all your medical conditions and all other medications (including over-the-counter drugs and herbal supplements) you are taking.
- If you experience severe dizziness, vision changes, or irregular heartbeat, seek immediate medical attention.
Missed Dose Advice
If you miss a dose of Nauset, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Nauset may cause dizziness or drowsiness in some individuals. Patients should be advised to exercise caution when driving or operating machinery until they know how this medication affects them.
Lifestyle Advice
- Avoid driving or operating heavy machinery if you experience dizziness or drowsiness after taking this medication.
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