Navalexin
Generic Name
Navalexin 500 mg Capsule
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| navalexin 500 mg capsule | ৳ 9.00 | ৳ 90.00 |
Description
Overview of the medicine
Navalexin 500 mg Capsule is a broad-spectrum antibiotic belonging to the cephalosporin class, used to treat a wide range of bacterial infections. It works by preventing the growth of bacteria.
Uses & Indications
Dosage
Adults
250-500 mg every 8 hours, depending on the severity of infection.
Elderly
No specific dose adjustment required unless renal function is impaired.
Renal_impairment
Dosage adjustment required. For creatinine clearance 10-20 mL/min: 250 mg every 12 hours. For creatinine clearance <10 mL/min: 250 mg every 24 hours.
How to Take
Navalexin capsules should be taken orally with water, preferably with food to minimize gastrointestinal upset. Complete the full course of treatment as prescribed by the doctor.
Mechanism of Action
Navalexin interferes with bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and bacterial death. It is bactericidal.
Pharmacokinetics
Onset
Within 1-2 hours of administration.
Excretion
Mainly by the kidneys via glomerular filtration and tubular secretion.
Half life
Approximately 1-2 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; peak plasma concentrations achieved within 1-2 hours.
Metabolism
Minimally metabolized; primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to cephalosporins or other beta-lactam antibiotics
- History of severe allergic reaction to penicillin
Drug Interactions
Metformin
May increase plasma concentration of metformin, requiring dose adjustment.
Probenecid
Increases plasma concentration and prolongs the half-life of Navalexin.
Antacids/Iron Supplements
Reduced absorption if taken simultaneously. Administer Navalexin at least 2 hours before or 4 hours after these agents.
Oral Anticoagulants (e.g., Warfarin)
May increase anticoagulant effect, requiring closer INR monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and rarely, convulsions. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal if recent ingestion. Hemodialysis may be useful.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to cephalosporins or other beta-lactam antibiotics
- History of severe allergic reaction to penicillin
Drug Interactions
Metformin
May increase plasma concentration of metformin, requiring dose adjustment.
Probenecid
Increases plasma concentration and prolongs the half-life of Navalexin.
Antacids/Iron Supplements
Reduced absorption if taken simultaneously. Administer Navalexin at least 2 hours before or 4 hours after these agents.
Oral Anticoagulants (e.g., Warfarin)
May increase anticoagulant effect, requiring closer INR monitoring.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and rarely, convulsions. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal if recent ingestion. Hemodialysis may be useful.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk in small amounts; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have established the efficacy and safety of cephalosporins for bacterial infections. Specific trials for Navalexin ensure its bioequivalence and therapeutic interchangeability with reference products.
Lab Monitoring
- Renal function tests (e.g., creatinine, BUN) for prolonged therapy or in patients with pre-existing renal impairment.
- Complete blood count (CBC) for prolonged therapy.
Doctor Notes
- Counsel patients on completing the full course of treatment.
- Monitor for signs of allergic reactions, especially in patients with penicillin allergy history.
- Adjust dose in renal impairment.
Patient Guidelines
- Take the medicine for the full prescribed duration, even if symptoms improve.
- Do not share your medicine with others.
- Inform your doctor about any allergies or other medications you are taking.
- Contact your doctor if you experience severe diarrhea or allergic reactions.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
Navalexin is generally not expected to affect the ability to drive or operate machinery. However, if dizziness or headache occurs, avoid such activities.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Drink plenty of fluids to stay hydrated.
- Avoid alcohol during treatment.
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Global Brand Names
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