Neugalin
Generic Name
Pregabalin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neugalin 25 mg capsule | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Pregabalin is an anticonvulsant and neuropathic pain agent used to treat neuropathic pain, epilepsy, and generalized anxiety disorder.
Uses & Indications
Dosage
Adults
Initial 75 mg twice daily or 50 mg three times daily, titrated up to 150-300 mg twice daily or 100-200 mg three times daily based on indication and response. Max 600 mg/day.
Elderly
Dosage adjustment may be required due to decreased renal function. Start with lower doses.
Renal_impairment
Dosage must be reduced based on creatinine clearance.
How to Take
Oral, with or without food.
Mechanism of Action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of various excitatory neurotransmitters, leading to analgesic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Within 1 week for neuropathic pain; varies for other indications.
Excretion
Primarily excreted unchanged in the urine.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are typically achieved within 1 hour. Bioavailability is ≥ 90%.
Metabolism
Negligible hepatic metabolism.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any excipients.
Drug Interactions
Angiotensin Converting Enzyme (ACE) Inhibitors
May increase risk of angioedema.
CNS Depressants (e.g., opioids, benzodiazepines, ethanol)
Increased risk of additive CNS depression.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms include somnolence, confusion, agitation, and coma. Treatment is supportive and may include gastric lavage or hemodialysis if severe.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk. Not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any excipients.
Drug Interactions
Angiotensin Converting Enzyme (ACE) Inhibitors
May increase risk of angioedema.
CNS Depressants (e.g., opioids, benzodiazepines, ethanol)
Increased risk of additive CNS depression.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms include somnolence, confusion, agitation, and coma. Treatment is supportive and may include gastric lavage or hemodialysis if severe.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Excreted in breast milk. Not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 years
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of pregabalin across its approved indications, including neuropathic pain, epilepsy, and generalized anxiety disorder.
Lab Monitoring
- Renal function, particularly if patient has kidney impairment.
Doctor Notes
- Counsel patients on potential for dizziness and somnolence and the importance of avoiding driving or operating machinery until effects are known.
- Emphasize gradual discontinuation to minimize withdrawal symptoms.
- Monitor for signs of suicidal ideation, especially at the beginning of treatment or during dose changes.
Patient Guidelines
- Do not stop Neugalin abruptly to avoid withdrawal symptoms.
- Avoid driving or operating machinery until you know how the medicine affects you.
- Report any unusual mood changes or suicidal thoughts to your doctor immediately.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double dose.
Driving Precautions
May cause dizziness and somnolence; avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid alcohol consumption while taking Neugalin.
- Maintain a healthy lifestyle with regular exercise and balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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