Neurobest
Generic Name
Thiamine Hydrochloride (B1) + Pyridoxine Hydrochloride (B6) + Cyanocobalamin (B12)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| neurobest 100 mg tablet | ৳ 10.00 | ৳ 100.00 |
| neurobest 100 mg injection | ৳ 30.00 | N/A |
Description
Overview of the medicine
Neurobest is a vitamin B complex preparation containing Thiamine (B1), Pyridoxine (B6), and Cyanocobalamin (B12). It is primarily used to treat and prevent deficiencies of these vitamins, particularly in conditions affecting the nervous system.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily or as directed by physician.
Elderly
No specific dose adjustment required unless significant renal impairment.
Renal_impairment
Use with caution in severe renal impairment; consult a physician.
How to Take
Oral tablets should be swallowed whole with water, preferably after meals.
Mechanism of Action
Thiamine (B1) acts as a coenzyme in carbohydrate metabolism. Pyridoxine (B6) is essential for amino acid and protein metabolism, and neurotransmitter synthesis. Cyanocobalamin (B12) is vital for DNA synthesis, red blood cell formation, and maintaining nerve myelin sheath.
Pharmacokinetics
Onset
Clinical effects may be noticeable within days to weeks depending on deficiency severity.
Excretion
Primarily renal excretion (urine) for B1 and B6; B12 is excreted through bile, with enterohepatic recirculation.
Half life
Thiamine: 18-36 hours; Pyridoxine: 15-20 days (active forms); Cyanocobalamin: 6 days (liver storage up to years).
Absorption
Well absorbed from the gastrointestinal tract; B12 absorption requires intrinsic factor.
Metabolism
Mainly in the liver, converted to active coenzyme forms.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Patients with Leber's disease (due to B12).
Drug Interactions
Levodopa
Pyridoxine (B6) may reduce the efficacy of Levodopa, especially without a decarboxylase inhibitor.
Phenobarbital, Phenytoin
Pyridoxine may decrease serum concentrations of these anticonvulsants.
Isoniazid, Oral Contraceptives
May increase pyridoxine requirements.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Overdose is rare due to water-soluble nature; however, very high doses of pyridoxine can lead to peripheral neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe in recommended doses. Consult a physician before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Patients with Leber's disease (due to B12).
Drug Interactions
Levodopa
Pyridoxine (B6) may reduce the efficacy of Levodopa, especially without a decarboxylase inhibitor.
Phenobarbital, Phenytoin
Pyridoxine may decrease serum concentrations of these anticonvulsants.
Isoniazid, Oral Contraceptives
May increase pyridoxine requirements.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Overdose is rare due to water-soluble nature; however, very high doses of pyridoxine can lead to peripheral neuropathy. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Generally considered safe in recommended doses. Consult a physician before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA as a vitamin supplement
Patent Status
No patent (generic formulation)
Clinical Trials
Extensive clinical data supports the use of B vitamins for deficiency states and neuropathies.
Lab Monitoring
- Not typically required for routine use. May monitor B vitamin levels in severe deficiency or malabsorption conditions.
Doctor Notes
- Consider ruling out other causes of neuropathy before initiating B vitamin therapy.
- Monitor patients for symptoms of B6 toxicity if on high doses long-term.
Patient Guidelines
- Take as directed by your doctor or pharmacist.
- Do not exceed the recommended dose.
- Inform your doctor about all medications and supplements you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Maintain a balanced diet rich in B vitamins.
- Avoid excessive alcohol consumption, as it can deplete B vitamins.
- Regular exercise and stress management can support overall health.
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