Nolargy
Generic Name
Fexofenadine Hydrochloride 180 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| nolargy 180 mg tablet | ৳ 8.00 | N/A |
Description
Overview of the medicine
Nolargy 180 mg Tablet contains fexofenadine hydrochloride, a non-sedating antihistamine used to relieve symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
For seasonal allergic rhinitis and chronic idiopathic urticaria: 180 mg orally once daily.
Elderly
No dosage adjustment is generally required for elderly patients unless they have impaired renal function.
Renal_impairment
For adult patients with impaired renal function (creatinine clearance ≤80 mL/min), the recommended starting dose is 60 mg once daily.
How to Take
Take Nolargy 180 mg Tablet orally, with or without food. It is recommended to avoid taking it with fruit juices (e.g., grapefruit, orange, apple juice) as they may reduce the bioavailability of fexofenadine.
Mechanism of Action
Fexofenadine selectively antagonizes peripheral H1-receptors, thereby inhibiting the effects of histamine and alleviating allergy symptoms without significant penetration of the blood-brain barrier, which contributes to its non-sedating profile.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Primarily excreted unchanged in feces (80%) and urine (11%).
Half life
Approximately 11 to 15 hours
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 1 to 3 hours.
Metabolism
Minimally metabolized (approximately 5%) in the liver, primarily via CYP3A4 pathway.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine hydrochloride or any of the excipients in the formulation.
Drug Interactions
Erythromycin and Ketoconazole
Co-administration with erythromycin or ketoconazole may result in increased plasma levels of fexofenadine. Monitor for potential increased side effects.
Antacids (aluminum and magnesium containing)
Co-administration with aluminum- and magnesium-containing antacids within 15 minutes can reduce fexofenadine bioavailability. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms like dizziness, drowsiness, and dry mouth have been reported. Management should be symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Known hypersensitivity to fexofenadine hydrochloride or any of the excipients in the formulation.
Drug Interactions
Erythromycin and Ketoconazole
Co-administration with erythromycin or ketoconazole may result in increased plasma levels of fexofenadine. Monitor for potential increased side effects.
Antacids (aluminum and magnesium containing)
Co-administration with aluminum- and magnesium-containing antacids within 15 minutes can reduce fexofenadine bioavailability. Separate administration by at least 2 hours.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms like dizziness, drowsiness, and dry mouth have been reported. Management should be symptomatic and supportive. Hemodialysis does not effectively remove fexofenadine from blood.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Fexofenadine is excreted into breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
Clinical Trials
Fexofenadine has been extensively studied in clinical trials demonstrating its efficacy and safety for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- Routine laboratory monitoring is generally not required for patients taking fexofenadine.
Doctor Notes
- Advise patients to avoid concurrent use with fruit juices (grapefruit, orange, apple) due to potential reduction in bioavailability.
- Counsel patients that although generally non-sedating, individual responses can vary, and caution should be exercised before activities requiring mental alertness.
Patient Guidelines
- Take Nolargy exactly as prescribed by your doctor.
- Do not take more than the recommended dose.
- Avoid consuming fruit juices (grapefruit, orange, apple) within 2 hours of taking this medication.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Nolargy is generally considered non-sedating, but individual responses can vary. It is advisable to observe your reaction to the medication before driving or operating machinery.
Lifestyle Advice
- Identify and avoid known allergens to help manage allergy symptoms.
- Ensure adequate hydration while on medication.
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