Medicine Information

Nolargy

Name: Nolargy
Brand: Nolargy
Rating: 4.5 (117 reviews)

Tablet120 mgAntihistamine (H1 receptor antagonist)ATC: R06AX26

Generic Name

Fexofenadine Hydrochloride

Manufacturer

Example Pharmaceutical Co. Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
nolargy 120 mg tablet	৳ 6.50	N/A

Description

Overview of the medicine

Nolargy 120 mg tablet contains Fexofenadine Hydrochloride, a non-drowsy antihistamine used to relieve symptoms of seasonal allergic rhinitis (hay fever) and chronic idiopathic urticaria (hives).

Uses & Indications

Seasonal allergic rhinitis (hay fever)

Chronic idiopathic urticaria

Dosage

Adults

For seasonal allergic rhinitis, 120 mg orally once daily. For chronic idiopathic urticaria, 180 mg orally once daily.

Elderly

No specific dose adjustment is generally required for elderly patients, but renal function should be considered.

Renal_impairment

For patients with impaired renal function, a starting dose of 60 mg once daily is recommended.

How to Take

Take Nolargy 120 mg tablet orally, preferably before a meal, with a glass of water. Do not take with fruit juices as they may reduce absorption.

Mechanism of Action

Fexofenadine is a selective peripheral H1-blocker. It works by blocking histamine H1 receptors, thereby preventing the effects of histamine which cause allergy symptoms such as sneezing, runny nose, itchy eyes, and skin rashes.

Pharmacokinetics

Onset

Onset of action typically occurs within 1 hour.

Excretion

Approximately 80% is excreted in the feces and 11% in the urine, primarily as unchanged drug.

Half life

The elimination half-life is approximately 11-15 hours.

Absorption

Rapidly absorbed after oral administration. Peak plasma concentrations (Cmax) are reached approximately 2-3 hours after a dose.

Metabolism

Fexofenadine undergoes minimal hepatic metabolism (less than 5% of the total dose is metabolized).

Side Effects

Contraindications

Hypersensitivity to fexofenadine or any components of the tablet.

Drug Interactions

Erythromycin and Ketoconazole

Concomitant use with these drugs may increase fexofenadine plasma concentrations, but this increase is generally not considered clinically significant.

Aluminum- and magnesium-containing antacids

These antacids can reduce the absorption of fexofenadine; separate administration by approximately 2 hours.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Overdose symptoms may include dizziness, drowsiness, and dry mouth. Management involves symptomatic and supportive treatment. Hemodialysis is not effective in removing fexofenadine.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not recommended during breastfeeding as fexofenadine is excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1 strip)30 tablets (3 strips)

Shelf Life

Typically 24-36 months from the date of manufacture.

Availability

Available in pharmacies nationwide

Approval Status

Approved by regulatory bodies (e.g., DGDA, FDA)

Patent Status

Generic available, original patent expired

Clinical Trials

Fexofenadine has undergone extensive clinical trials demonstrating its efficacy and safety in treating seasonal allergic rhinitis and chronic idiopathic urticaria, showing significant symptom relief with a low incidence of sedation.

Lab Monitoring

No routine laboratory monitoring is typically required.

Doctor Notes

Advise patients to avoid taking fexofenadine with fruit juices as it can significantly reduce efficacy.
Consider dose adjustment in patients with renal impairment.
Reassure patients that it is a non-sedating antihistamine, but to observe individual response.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not take more than the recommended dose.
Avoid taking with fruit juices (grapefruit, orange, apple) as they can reduce the medicine's effectiveness.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

While fexofenadine is generally non-sedating, individual responses can vary. Patients should exercise caution when driving or operating machinery until they know how the medicine affects them.