Odacef
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| odacef 400 mg capsule | ৳ 55.00 | ৳ 385.00 |
Description
Overview of the medicine
Odacef 400 mg Capsule contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections in various parts of the body.
Uses & Indications
Dosage
Adults
The usual adult dose is 400 mg once daily or 200 mg twice daily. Duration of treatment depends on the type and severity of infection, typically 7 to 14 days.
Elderly
Same as adults, but dose adjustment may be necessary in patients with severe renal impairment.
Renal_impairment
For creatinine clearance 21-60 mL/min, 300 mg daily. For creatinine clearance <20 mL/min, 200 mg daily. Hemodialysis and peritoneal dialysis patients may require dose adjustment.
How to Take
Odacef 400 mg Capsule is for oral administration. It can be taken with or without food. To ensure complete absorption and effectiveness, it should be swallowed whole with water.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death (bactericidal action). It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which interferes with the final transpeptidation step of peptidoglycan synthesis.
Pharmacokinetics
Onset
Peak plasma concentrations are usually achieved within 2-6 hours after oral administration.
Excretion
Approximately 50% of the absorbed dose is excreted unchanged in the urine over 24 hours, and about 10% is excreted in bile.
Half life
Plasma elimination half-life is typically 3-4 hours in healthy adults.
Absorption
Approximately 40-50% orally absorbed. Food slightly prolongs Tmax but does not significantly alter Cmax or AUC.
Metabolism
Minimal hepatic metabolism; Cefixime is primarily excreted as unchanged drug.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Carbamazepine
Concomitant use may increase carbamazepine plasma concentrations. Monitor carbamazepine levels.
Warfarin and other anticoagulants
May increase prothrombin time/INR, leading to increased bleeding risk. Monitor INR closely.
Aminoglycosides and Loop Diuretics
May increase risk of nephrotoxicity, especially in patients with impaired renal function.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis does not effectively remove Cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to Cefixime or any other cephalosporin antibiotics.
- History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.
Drug Interactions
Carbamazepine
Concomitant use may increase carbamazepine plasma concentrations. Monitor carbamazepine levels.
Warfarin and other anticoagulants
May increase prothrombin time/INR, leading to increased bleeding risk. Monitor INR closely.
Aminoglycosides and Loop Diuretics
May increase risk of nephrotoxicity, especially in patients with impaired renal function.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, gastric lavage may be indicated. There is no specific antidote. Treatment should be symptomatic and supportive. Hemodialysis or peritoneal dialysis does not effectively remove Cefixime from the body.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Cefixime is excreted in small amounts in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established Cefixime's efficacy and safety for indicated bacterial infections. Further trials explore its use in specific patient populations or novel formulations.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Complete blood count (CBC) during prolonged therapy.
Doctor Notes
- Always consider local susceptibility patterns when prescribing Cefixime.
- Adjust dose for patients with significant renal impairment.
- Educate patients on the importance of completing the full course of therapy.
Patient Guidelines
- Take the medicine for the full prescribed duration, even if symptoms improve, to prevent recurrence and development of antibiotic resistance.
- Do not share this medicine with others, even if they have similar symptoms.
- Inform your doctor about any new or worsening symptoms or side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Odacef is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or other adverse effects that could affect concentration, avoid such activities.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Consider consuming probiotics (e.g., yogurt) to help maintain healthy gut flora, especially during and after antibiotic treatment.
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