Omastin
Generic Name
Omeprazole
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omastin 150 mg capsule | ৳ 22.00 | ৳ 220.00 |
Description
Overview of the medicine
Omastin 150 mg Capsule is an extended-release formulation of Omeprazole, a proton pump inhibitor (PPI) used to reduce stomach acid production. It is typically prescribed for severe acid-related conditions, such as Zollinger-Ellison Syndrome or refractory gastroesophageal reflux disease (GERD), where higher doses are required.
Uses & Indications
Dosage
Adults
For Zollinger-Ellison Syndrome, the initial recommended dose is 60 mg once daily. Doses can be adjusted based on individual response, with some patients requiring up to 120-150 mg once daily or divided doses. For severe erosive esophagitis/refractory GERD, doses higher than 40 mg daily may be considered by a physician, with 150 mg possibly used for extreme cases.
Elderly
No specific dosage adjustment based on age alone is typically required; however, caution is advised due to potential comorbidities and polypharmacy. Monitor for adverse effects.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule whole with a glass of water. Do not chew, crush, or open the capsule, as this may affect the extended-release properties. It is best taken before a meal, preferably in the morning, to ensure optimal acid suppression throughout the day.
Mechanism of Action
Omeprazole is a proton pump inhibitor that irreversibly binds to and inhibits the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This action effectively blocks the final step in gastric acid secretion, significantly reducing both basal and stimulated acid production.
Pharmacokinetics
Onset
Acid suppression begins within 1-2 hours after administration. Full therapeutic effect typically within 2-4 days.
Excretion
Approximately 77% of the dose is excreted in the urine, and the remainder is excreted in the feces via biliary secretion.
Half life
Plasma elimination half-life is short (0.5 to 1 hour), but the duration of acid suppression is much longer (up to 72 hours) due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed from the gastrointestinal tract, but the extended-release formulation delays and prolongs absorption, leading to sustained plasma levels and therapeutic effect. Bioavailability is approximately 30-65%.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 enzyme system, specifically CYP2C19 and CYP3A4, into inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Omeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with Nelfinavir (an antiretroviral drug) due to significant reduction in Nelfinavir plasma concentrations.
Drug Interactions
Digoxin
Increased Digoxin levels due to increased gastric pH.
Warfarin
Increased INR and bleeding risk, requiring careful monitoring.
Clopidogrel
Reduced antiplatelet effect of Clopidogrel due to inhibition of its activation via CYP2C19.
Methotrexate
Increased and prolonged Methotrexate serum levels, especially with high doses, potentially leading to toxicity.
Atazanavir, Nelfinavir
Reduced absorption and efficacy of these antiretrovirals due to increased gastric pH.
Ketoconazole, Itraconazole, Erlotinib
Reduced absorption due to increased gastric pH.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Limited information on overdose is available. Symptoms may include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. Omeprazole is not dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Omeprazole is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (hypothetical)
Patent Status
Off-patent (for Omeprazole)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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