Omegut
Generic Name
Omeprazole
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omegut 20 mg capsule | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor (PPI) that works by decreasing the amount of acid your stomach makes. It is used to treat heartburn, stomach ulcers, and gastroesophageal reflux disease (GERD).
Uses & Indications
Dosage
Adults
Usually 20 mg once daily for 4-8 weeks, depending on the condition. For severe conditions, it may be increased to 40 mg once daily. For H. pylori eradication, 20 mg twice daily with antibiotics for 7-14 days.
Elderly
No specific dose adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule whole with water, preferably in the morning before a meal. Do not chew or crush the capsule.
Mechanism of Action
Omeprazole irreversibly inhibits the H+/K+-ATPase (proton pump) in the secretory canaliculi of the gastric parietal cells. This reduces gastric acid secretion.
Pharmacokinetics
Onset
Within 1-2 hours.
Excretion
Approximately 80% is excreted in urine as metabolites, and the remainder in feces.
Half life
Plasma elimination half-life is 0.5-1 hour, but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed from the gastrointestinal tract, but absorption is variable. Bioavailability increases with repeated administration. Food may delay absorption.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with Nelfinavir.
Drug Interactions
Diazepam
Decreased clearance of diazepam.
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of Clopidogrel.
Methotrexate
Increased plasma levels of methotrexate.
Nelfinavir/Atazanavir
Reduced plasma concentrations of these antiviral drugs.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Omeprazole is excreted into human breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with Nelfinavir.
Drug Interactions
Diazepam
Decreased clearance of diazepam.
Warfarin
Increased INR/prothrombin time.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of Clopidogrel.
Methotrexate
Increased plasma levels of methotrexate.
Nelfinavir/Atazanavir
Reduced plasma concentrations of these antiviral drugs.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Omeprazole is excreted into human breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (check specific packaging)
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic drug, patents expired
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for its approved indications.
Lab Monitoring
- For long-term use (more than 3 months), periodically monitor magnesium levels. For prolonged therapy (more than 2 years), consider monitoring Vitamin B12 levels.
Doctor Notes
- Prescribe at the lowest effective dose for the shortest duration necessary.
- Consider screening for H. pylori before initiating long-term therapy for dyspepsia.
- Monitor for potential drug interactions, especially with Clopidogrel and Warfarin.
- Educate patients on lifestyle modifications to aid treatment.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor.
- Swallow the capsule whole; do not chew, crush, or open it.
- Take it preferably in the morning before your first meal.
- Avoid alcohol and smoking as they can worsen acid reflux.
- Do not stop taking the medication abruptly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally, omeprazole does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Elevate the head of your bed (for GERD).
- Avoid trigger foods (spicy, fatty, acidic foods, caffeine).
- Eat smaller, more frequent meals.
- Maintain a healthy weight.
- Avoid eating late at night.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Omegut Brand
Other medicines available under the same brand name
