Omegut
Generic Name
Omeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omegut 40 mg injection | ৳ 80.00 | N/A |
Description
Overview of the medicine
Omegut 40 mg Injection contains Omeprazole, a proton pump inhibitor, used to reduce stomach acid production. It is prescribed for severe acid-related conditions, especially when oral administration is not possible.
Uses & Indications
Dosage
Adults
Usually 40 mg once daily by intravenous infusion. In severe cases, 40 mg twice daily. Infusion duration: 20-30 minutes.
Elderly
No dose adjustment typically required unless severe hepatic impairment.
Renal_impairment
No dose adjustment required.
How to Take
Reconstitute the lyophilized powder with 100 ml of 0.9% sodium chloride or 5% dextrose solution. Administer as an intravenous infusion over 20-30 minutes.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase proton pump in gastric parietal cells, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Acid suppression begins within 30-60 minutes.
Excretion
Mainly excreted in urine (approximately 80%) and in feces (approximately 20%).
Half life
Approximately 0.5-1 hour, but duration of acid suppression is up to 72 hours.
Absorption
Rapid and complete absorption after intravenous administration, 100% bioavailability.
Metabolism
Extensively metabolized in the liver by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin bioavailability (monitor digoxin levels).
Warfarin
Altered INR and bleeding risk (monitor INR).
Nelfinavir
Significant reduction in nelfinavir plasma levels (contraindicated).
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use).
Methotrexate
Increased plasma levels of methotrexate (monitor closely).
Storage
Store below 30°C, protected from light. Reconstituted solution should be used within 12 hours if stored at 25°C, or within 24 hours if stored at 2-8°C.
Overdose
Symptoms are generally mild and self-limiting (nausea, vomiting, abdominal pain, diarrhea, headache). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and potential benefits outweigh risks. Caution is advised during lactation; consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Digoxin
Increased digoxin bioavailability (monitor digoxin levels).
Warfarin
Altered INR and bleeding risk (monitor INR).
Nelfinavir
Significant reduction in nelfinavir plasma levels (contraindicated).
Clopidogrel
Reduced antiplatelet effect of clopidogrel (avoid concomitant use).
Methotrexate
Increased plasma levels of methotrexate (monitor closely).
Storage
Store below 30°C, protected from light. Reconstituted solution should be used within 12 hours if stored at 25°C, or within 24 hours if stored at 2-8°C.
Overdose
Symptoms are generally mild and self-limiting (nausea, vomiting, abdominal pain, diarrhea, headache). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and potential benefits outweigh risks. Caution is advised during lactation; consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months. Refer to the product's specific expiry date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA and internationally
Patent Status
Patent expired, available generically
WHO Essential Medicine
YesClinical Trials
Omeprazole's efficacy and safety have been established through extensive clinical trials for various acid-related disorders, supporting its use as a standard treatment.
Lab Monitoring
- Serum magnesium levels (especially with prolonged use or concurrent use of other magnesium-lowering drugs)
- Liver function tests (if hepatic impairment is suspected)
Doctor Notes
- Intravenous omeprazole is indicated for patients unable to take oral therapy.
- Ensure proper reconstitution and infusion rate to avoid adverse reactions.
- Monitor for signs of C. difficile-associated diarrhea, especially in hospitalized patients.
Patient Guidelines
- Inform your doctor about all current medications, including over-the-counter drugs and herbal supplements.
- Report any unusual symptoms such as severe diarrhea, bone pain, or unexplained weight loss.
- This injection is for short-term use in most cases; your doctor will advise when to switch to oral therapy.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine may cause dizziness or visual disturbances. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid smoking and excessive alcohol consumption, as these can exacerbate acid-related conditions.
- Maintain a healthy diet and avoid foods that trigger acid reflux.
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