Omeprol
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omeprol 20 mg capsule | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor (PPI) that decreases the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Duodenal ulcer: 20 mg once daily for 2-4 weeks. Gastric ulcer: 20 mg once daily for 4-8 weeks. H. pylori eradication: 20 mg twice daily with antibiotics. Zollinger-Ellison syndrome: Initial 60 mg once daily, adjusted as needed.
Elderly
No specific dosage adjustment usually required, but caution with hepatic impairment.
Renal_impairment
No dosage adjustment needed for renal impairment.
How to Take
For oral use. Take the capsule whole with water, preferably in the morning before a meal. Do not chew or crush the capsule.
Mechanism of Action
Omeprazole irreversibly binds to and inhibits the H+/K+-ATPase (proton pump) in the secretory canaliculi of parietal cells in the stomach. This blockade of the proton pump prevents the secretion of hydrogen ions into the gastric lumen, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Within 1-2 hours, maximal effect after 2-4 days of continuous treatment.
Excretion
Mainly via urine (approx. 77%), remainder via feces.
Half life
0.5-1 hour (terminal elimination half-life is longer due to irreversible binding).
Absorption
Rapidly absorbed from the gastrointestinal tract, bioavailability about 30-40% (increases with repeated doses).
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any PPIs
- Co-administration with nelfinavir
Drug Interactions
Warfarin
Increased INR/bleeding risk.
Tacrolimus
Increased tacrolimus levels.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel (CYP2C19 inhibition).
Methotrexate
Increased methotrexate levels.
Diazepam, Phenytoin, Citalopram
Increased levels due to CYP2C19 inhibition.
HIV antivirals (e.g., Atazanavir, Nelfinavir)
Reduced absorption due to altered gastric pH.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and reversible, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. No specific antidote. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed after careful risk-benefit assessment. Omeprazole is excreted in human breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any PPIs
- Co-administration with nelfinavir
Drug Interactions
Warfarin
Increased INR/bleeding risk.
Tacrolimus
Increased tacrolimus levels.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel (CYP2C19 inhibition).
Methotrexate
Increased methotrexate levels.
Diazepam, Phenytoin, Citalopram
Increased levels due to CYP2C19 inhibition.
HIV antivirals (e.g., Atazanavir, Nelfinavir)
Reduced absorption due to altered gastric pH.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and reversible, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. No specific antidote. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed after careful risk-benefit assessment. Omeprazole is excreted in human breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Omeprazole has been extensively studied and proven effective in numerous clinical trials for its indicated uses, including GERD, peptic ulcers, and H. pylori eradication.
Lab Monitoring
- Magnesium levels (for long-term use)
- Vitamin B12 levels (for long-term use)
- Liver function tests (if hepatic impairment suspected)
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Evaluate for C. difficile if diarrhea persists.
- Monitor for bone mineral density and B12/magnesium in long-term users.
Patient Guidelines
- Take before food, preferably in the morning.
- Do not chew or crush the capsule.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a forgotten one.
Driving Precautions
Omeprazole may cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Elevate the head of your bed if you have GERD symptoms at night.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Omeprol Brand
Other medicines available under the same brand name
