Omeprol
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omeprol 40 mg capsule | ৳ 7.00 | ৳ 56.00 |
Description
Overview of the medicine
Omeprol 40 mg Capsule contains Omeprazole, a proton pump inhibitor used to reduce stomach acid production. It is prescribed for conditions like gastroesophageal reflux disease (GERD), stomach ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD: 20-40 mg once daily for 4-8 weeks. For Duodenal Ulcer: 20 mg once daily for 2-4 weeks. For Gastric Ulcer: 20 mg once daily for 4-8 weeks. For Zollinger-Ellison Syndrome: Initial dose 60 mg once daily, adjusted based on patient response.
Elderly
No specific dose adjustment is required, but caution is advised in elderly patients with hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule whole with a glass of water, preferably in the morning before food. Do not chew or crush the capsule.
Mechanism of Action
Omeprazole is a proton pump inhibitor (PPI) that irreversibly binds to and inhibits the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This inhibition prevents the final step of acid secretion, thereby reducing gastric acidity.
Pharmacokinetics
Onset
Within 1 hour
Excretion
Mainly through urine (approx. 77%) and feces (approx. 23%) as metabolites.
Half life
0.5-1 hour (plasma half-life), but duration of acid inhibition is longer due to irreversible binding to proton pump.
Absorption
Rapidly but variably absorbed from the gastrointestinal tract; bioavailability is about 30-40% but increases with repeated dosing.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole or any component of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and bleeding risk.
Nelfinavir
Significantly reduced plasma concentration of nelfinavir.
Clopidogrel
Reduced antiplatelet effect due to CYP2C19 inhibition by omeprazole.
Methotrexate
Increased methotrexate levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is largely symptomatic and supportive. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Omeprazole or any component of the formulation
- Concomitant use with Nelfinavir
Drug Interactions
Digoxin
Increased digoxin levels.
Warfarin
Increased INR and bleeding risk.
Nelfinavir
Significantly reduced plasma concentration of nelfinavir.
Clopidogrel
Reduced antiplatelet effect due to CYP2C19 inhibition by omeprazole.
Methotrexate
Increased methotrexate levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is largely symptomatic and supportive. No specific antidote is known.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts are excreted in breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date, depending on specific formulation and manufacturer.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available (Patent expired for original molecule)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of omeprazole for various acid-related disorders. Ongoing research focuses on long-term effects and comparisons with other PPIs.
Lab Monitoring
- Liver function tests (in patients with hepatic impairment)
- Magnesium levels (with long-term use)
- Chromogranin A (CgA) levels (can interfere with neuroendocrine tumor diagnosis)
Doctor Notes
- Counsel patients on potential long-term risks with PPIs.
- Consider lowest effective dose and shortest duration of therapy.
- Assess for drug interactions, especially with antiplatelets and antivirals.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
- Report any severe or persistent side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Omeprazole is generally considered safe for driving. However, some patients may experience dizziness or visual disturbances, in which case driving or operating machinery should be avoided.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty, acidic foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Elevate the head of your bed if you suffer from GERD.
- Avoid lying down immediately after meals.
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Global Brand Names
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