Omeprol
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omeprol 40 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Omeprol 40 mg injection is used for the treatment of various acid-related disorders when oral administration is not feasible.
Uses & Indications
Dosage
Adults
Usually 40 mg once daily by intravenous infusion for 20-30 minutes. In Zollinger-Ellison Syndrome, the initial dose is 60 mg once daily.
Elderly
No specific dosage adjustment is required, but caution is advised.
Renal_impairment
No dosage adjustment is needed.
Hepatic_impairment
Dosage reduction may be considered for severe hepatic impairment.
How to Take
Reconstitute the vial with 100 mL of 0.9% NaCl solution or 5% Dextrose solution. Administer as an intravenous infusion over a period of 20-30 minutes.
Mechanism of Action
Omeprazole irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells, thereby inhibiting the final step of gastric acid secretion.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Primarily via urine (approx. 80%) and feces (approx. 20%).
Half life
Approximately 0.5 to 1 hour (plasma), but effect lasts over 24 hours.
Absorption
Rapid absorption after IV administration.
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with Nelfinavir.
Drug Interactions
Clopidogrel
Reduced antiplatelet effect of Clopidogrel.
Methotrexate
Increased and prolonged serum levels of methotrexate.
Nelfinavir, Atazanavir
Reduced plasma levels of Nelfinavir/Atazanavir.
Warfarin, Phenytoin, Diazepam
Increased plasma levels of these drugs due to inhibition of CYP2C19.
Storage
Store below 30°C, protected from light and moisture. Reconstituted solution should be used within 12 hours if stored at 25°C or within 24 hours if stored at 2-8°C.
Overdose
Limited information on overdose. Symptoms are generally mild (nausea, vomiting, dizziness, abdominal pain). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if clearly needed. Omeprazole is excreted in breast milk; use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with Nelfinavir.
Drug Interactions
Clopidogrel
Reduced antiplatelet effect of Clopidogrel.
Methotrexate
Increased and prolonged serum levels of methotrexate.
Nelfinavir, Atazanavir
Reduced plasma levels of Nelfinavir/Atazanavir.
Warfarin, Phenytoin, Diazepam
Increased plasma levels of these drugs due to inhibition of CYP2C19.
Storage
Store below 30°C, protected from light and moisture. Reconstituted solution should be used within 12 hours if stored at 25°C or within 24 hours if stored at 2-8°C.
Overdose
Limited information on overdose. Symptoms are generally mild (nausea, vomiting, dizziness, abdominal pain). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if clearly needed. Omeprazole is excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, as per manufacturer's specifications.
Availability
Pharmacies, Hospitals
Approval Status
Approved (globally)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated omeprazole's efficacy and safety in various acid-related disorders.
Lab Monitoring
- Liver function tests (periodically)
- Serum magnesium levels (for prolonged therapy)
Doctor Notes
- For intravenous administration only; do not administer via any other route.
- Monitor liver function tests and magnesium levels during prolonged therapy.
- Consider potential drug interactions, especially with CYP2C19 substrates.
Patient Guidelines
- This medicine is administered by a healthcare professional.
- Inform your doctor about all existing medical conditions and other medications you are taking.
- Report any unusual or severe side effects immediately.
Missed Dose Advice
As this medicine is administered by a healthcare professional, a missed dose is unlikely. If a dose is missed, inform your doctor or nurse immediately.
Driving Precautions
May cause dizziness or visual disturbances; patients should exercise caution before driving or operating machinery.
Lifestyle Advice
- Follow your doctor's recommendations regarding diet and lifestyle changes to manage your condition effectively.
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Global Brand Names
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