Omex
Generic Name
Omeprazole
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omex 20 mg capsule | ৳ 5.02 | N/A |
Description
Overview of the medicine
Omeprazole is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions such as heartburn, acid reflux, and ulcers.
Uses & Indications
Dosage
Adults
Typical adult dosage is 20 mg once daily, taken before a meal. For severe conditions like Zollinger-Ellison Syndrome, higher doses (e.g., 60 mg once daily or divided) may be prescribed.
Elderly
No specific dose adjustment is generally required for elderly patients, but caution is advised in those with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take one capsule orally, usually in the morning before breakfast, with a glass of water. Do not chew or crush the capsule; swallow it whole.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase (proton pump) in the gastric parietal cells. This action prevents the final step of acid secretion, leading to a significant reduction in stomach acid.
Pharmacokinetics
Onset
Acid inhibitory effect starts within 1 hour, with maximum effect within 2 hours. Full acid suppression achieved after 4 days of treatment.
Excretion
Approximately 80% of the metabolites are excreted in the urine and about 20% in the feces.
Half life
Plasma elimination half-life is typically 0.5 to 1 hour, but the duration of acid suppression is much longer (up to 72 hours) due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 0.5 to 3.5 hours. Bioavailability is approximately 30-40% for a single dose but increases with repeated administration.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 enzymes CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels; monitor closely.
Warfarin
Increased INR/prothrombin time; monitor closely.
Tacrolimus
Increased tacrolimus levels; monitor closely.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel. Concomitant use should be avoided.
Methotrexate
May increase serum methotrexate levels; monitor closely.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals; co-administration is not recommended or contraindicated.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and reversible, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Omeprazole is excreted in human breast milk; a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Known hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Digoxin
Increased digoxin levels; monitor closely.
Warfarin
Increased INR/prothrombin time; monitor closely.
Tacrolimus
Increased tacrolimus levels; monitor closely.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel. Concomitant use should be avoided.
Methotrexate
May increase serum methotrexate levels; monitor closely.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals; co-administration is not recommended or contraindicated.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and reversible, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive. There is no specific antidote.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Omeprazole is excreted in human breast milk; a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Omeprazole has been extensively studied in numerous clinical trials establishing its efficacy and safety for various acid-related disorders.
Lab Monitoring
- Monitor magnesium levels, especially in patients on long-term therapy or taking other drugs that cause hypomagnesemia.
- Monitor for signs of Vitamin B12 deficiency with prolonged use.
Doctor Notes
- Advise patients to take the lowest effective dose for the shortest duration indicated.
- Consider monitoring magnesium levels in patients on prolonged PPI therapy.
- Educate patients on potential long-term risks.
Patient Guidelines
- Take the capsule whole; do not chew, crush, or open it.
- Take it before a meal, preferably in the morning.
- Inform your doctor about all other medications you are taking.
- Report any new or worsening symptoms to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Omeprazole may cause dizziness or visual disturbances in some patients. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods like spicy, fatty, or acidic items.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Elevate the head of your bed to reduce nighttime reflux.
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