Omex
Generic Name
Omeprazole
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omex 40 mg injection | ৳ 90.00 | N/A |
Description
Overview of the medicine
Omex 40 mg Injection contains omeprazole, a proton pump inhibitor used to reduce stomach acid production. It is indicated for conditions like ulcers, GERD, and Zollinger-Ellison syndrome, especially when oral therapy is not feasible.
Uses & Indications
Dosage
Adults
Typically 40 mg once daily for most indications. For severe Zollinger-Ellison Syndrome, higher doses may be required, up to 60 mg every 8 hours.
Elderly
No specific dose adjustment is generally required, but caution is advised with severe hepatic impairment.
Renal_impairment
No dose adjustment needed for renal impairment.
How to Take
For intravenous infusion only after reconstitution. Administer slowly over 20-30 minutes. Do not administer as a bolus injection.
Mechanism of Action
Omeprazole is a proton pump inhibitor that irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This reduces gastric acid secretion by inhibiting the final step in acid production.
Pharmacokinetics
Onset
Within 30-60 minutes after IV administration.
Excretion
Excreted mainly in the urine (approx. 77%) and feces (approx. 18%) as metabolites.
Half life
Approximately 0.5 to 1 hour (terminal half-life), but the duration of acid suppression is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed after intravenous administration, 100% bioavailability. Oral bioavailability is ~30-40% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Warfarin
Increased INR/prothrombin time; monitor closely.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19.
Methotrexate
Increased methotrexate levels; consider temporary discontinuation of PPI or lower methotrexate dose.
Nelfinavir/Atazanavir
Reduced plasma levels of antiretrovirals; co-administration is generally contraindicated.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children. Reconstituted solution should be used within 6 hours.
Overdose
Symptoms of overdose are generally mild and include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed after careful risk/benefit assessment. Omeprazole is excreted in human milk; caution should be exercised.
Side Effects
Contraindications
- Hypersensitivity to omeprazole or any component of the formulation
- Concomitant use with nelfinavir
Drug Interactions
Warfarin
Increased INR/prothrombin time; monitor closely.
Clopidogrel
Omeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19.
Methotrexate
Increased methotrexate levels; consider temporary discontinuation of PPI or lower methotrexate dose.
Nelfinavir/Atazanavir
Reduced plasma levels of antiretrovirals; co-administration is generally contraindicated.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children. Reconstituted solution should be used within 6 hours.
Overdose
Symptoms of overdose are generally mild and include nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy only if clearly needed after careful risk/benefit assessment. Omeprazole is excreted in human milk; caution should be exercised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date, check specific packaging for details.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of omeprazole for various acid-related disorders. Studies support its use in acute settings for GI bleeding and in patients unable to take oral medication.
Lab Monitoring
- Magnesium levels (with prolonged use)
- Vitamin B12 levels (with prolonged use)
Doctor Notes
- Ensure proper IV access and slow infusion rate.
- Monitor for signs of hypersensitivity reaction.
- Review necessity for continued PPI therapy periodically, especially for long-term use.
Patient Guidelines
- Inform your doctor about all your medical conditions and medications.
- Do not stop the medication suddenly without consulting your doctor.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy and fatty foods that may aggravate acid reflux.
- Elevate the head of your bed to reduce nighttime reflux symptoms.
- Avoid smoking and excessive alcohol consumption.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Omex Brand
Other medicines available under the same brand name
