Oticef
Generic Name
Cefixime
Manufacturer
ACI Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oticef 125 mg pediatric drop | ৳ 125.38 | N/A |
Description
Overview of the medicine
Oticef 125 mg Pediatric Drop is a third-generation cephalosporin antibiotic used to treat various bacterial infections such as urinary tract infections, otitis media (ear infections), pharyngitis, tonsillitis, and bronchitis in children.
Uses & Indications
Dosage
Adults
Not typically used for adults in this specific pediatric drop formulation; refer to adult formulations of Cefixime.
Elderly
Dose adjustment may be necessary based on renal function for elderly patients, as with adults.
Pediatric
Recommended dose is 8 mg/kg/day administered as a single dose or in two divided doses for 5-10 days.
Renal_impairment
Dosage should be adjusted in patients with severe renal impairment (creatinine clearance < 30 mL/min).
How to Take
Administer orally with or without food. Use the provided calibrated dropper or measuring spoon for accurate dosing. Shake well before each use.
Mechanism of Action
Cefixime works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved in 2-6 hours.
Excretion
Primarily excreted unchanged in the urine (about 50%) via glomerular filtration and tubular secretion.
Half life
The plasma half-life is typically 3-4 hours.
Absorption
Approximately 40-50% of orally administered cefixime is absorbed.
Metabolism
Cefixime is not extensively metabolized in the body.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or to any component of the formulation.
- History of serious hypersensitivity reactions to penicillin.
Drug Interactions
Nifedipine
May increase cefixime bioavailability.
Carbamazepine
Cefixime may increase carbamazepine plasma concentrations.
Oral Anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, requiring close monitoring of INR and prothrombin time.
Storage
Store the dry powder below 30°C in a dry place, away from light. Store the reconstituted suspension in a refrigerator (2-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed and prescribed by a doctor. Cefixime is excreted in small amounts in human milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Known hypersensitivity to cefixime, other cephalosporins, or to any component of the formulation.
- History of serious hypersensitivity reactions to penicillin.
Drug Interactions
Nifedipine
May increase cefixime bioavailability.
Carbamazepine
Cefixime may increase carbamazepine plasma concentrations.
Oral Anticoagulants (e.g., Warfarin)
May increase the anticoagulant effect, requiring close monitoring of INR and prothrombin time.
Storage
Store the dry powder below 30°C in a dry place, away from light. Store the reconstituted suspension in a refrigerator (2-8°C) and do not freeze.
Overdose
In case of overdose, gastric lavage may be indicated. Symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. Use during pregnancy only if clearly needed and prescribed by a doctor. Cefixime is excreted in small amounts in human milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Dry powder: 2-3 years. Reconstituted suspension: 7-14 days when stored in a refrigerator (2-8°C).
Availability
Pharmacies, Hospitals
Approval Status
DGDA Approved
Patent Status
Generic Available
WHO Essential Medicine
YesClinical Trials
Cefixime has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections across different age groups, particularly in pediatric populations.
Lab Monitoring
- For prolonged therapy, periodic assessment of renal function and blood counts may be advisable.
Doctor Notes
- Emphasize the importance of completing the full prescribed course to prevent the development of antibiotic resistance.
- Monitor patients for signs of C. difficile-associated diarrhea, especially with prolonged use.
- Advise parents on proper measurement and administration techniques for pediatric drops.
Patient Guidelines
- Complete the full course of medication as prescribed by your doctor, even if symptoms improve.
- Do not save medication for future use or share it with others.
- Store the reconstituted suspension in the refrigerator.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Cefixime generally does not impair the ability to drive or operate machinery. However, if you experience dizziness, caution is advised.
Lifestyle Advice
- Maintain adequate hydration by drinking plenty of fluids.
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