Oticef
Generic Name
Cefadroxil
Manufacturer
Opsonin Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oticef 500 mg capsule | ৳ 40.12 | ৳ 160.48 |
Description
Overview of the medicine
Oticef 500 mg Capsule contains Cefadroxil, a first-generation cephalosporin antibiotic used to treat various bacterial infections, including urinary tract infections, skin and soft tissue infections, and pharyngitis/tonsillitis.
Uses & Indications
Dosage
Adults
For most infections, 500 mg to 1 g once or twice daily, depending on the severity and type of infection. For uncomplicated UTIs, 1-2 g/day in single or divided doses. For skin/soft tissue infections, 1 g/day in single or divided doses. For pharyngitis/tonsillitis, 1 g/day in single or divided doses for 10 days.
Elderly
Similar to adult dosage, but caution and dosage adjustment may be needed based on renal function.
Renal_impairment
Dosage must be adjusted based on creatinine clearance. For CrCl 50-25 mL/min, 500 mg every 12 hours; for CrCl 25-10 mL/min, 500 mg every 24 hours; for CrCl <10 mL/min, 500 mg every 36 hours. A loading dose of 1000 mg may be given for severe infections.
How to Take
Take orally with a glass of water, with or without food. Food may help reduce potential gastrointestinal upset.
Mechanism of Action
Cefadroxil is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.
Pharmacokinetics
Onset
Rapid, with therapeutic concentrations achieved shortly after administration.
Excretion
Primarily excreted unchanged by the kidneys, through both glomerular filtration and tubular secretion. Over 90% of the dose is excreted in urine within 24 hours.
Half life
Approximately 1.5 to 2 hours in individuals with normal renal function.
Absorption
Well absorbed orally (over 90%), even in the presence of food, reaching peak plasma concentrations within 1-2 hours.
Metabolism
Not extensively metabolized in the liver; it remains largely unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefadroxil, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reactions to penicillins or other beta-lactam antibiotics (due to potential cross-reactivity).
Drug Interactions
Probenecid
May decrease the renal excretion of cefadroxil, leading to increased and prolonged plasma concentrations.
Aminoglycosides/Loop Diuretics
Concomitant use with other nephrotoxic drugs may increase the risk of nephrotoxicity.
Oral Anticoagulants (e.g., Warfarin)
Cephalosporins may enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. INR monitoring is recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Management is primarily supportive. Hemodialysis may be useful in the event of severe renal impairment or massive overdose.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefadroxil is excreted in small amounts into breast milk; caution should be exercised when administered to a nursing mother, though generally considered compatible with breastfeeding.
Side Effects
Contraindications
- Known hypersensitivity to cefadroxil, other cephalosporins, or any component of the formulation.
- History of severe hypersensitivity reactions to penicillins or other beta-lactam antibiotics (due to potential cross-reactivity).
Drug Interactions
Probenecid
May decrease the renal excretion of cefadroxil, leading to increased and prolonged plasma concentrations.
Aminoglycosides/Loop Diuretics
Concomitant use with other nephrotoxic drugs may increase the risk of nephrotoxicity.
Oral Anticoagulants (e.g., Warfarin)
Cephalosporins may enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. INR monitoring is recommended.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Management is primarily supportive. Hemodialysis may be useful in the event of severe renal impairment or massive overdose.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefadroxil is excreted in small amounts into breast milk; caution should be exercised when administered to a nursing mother, though generally considered compatible with breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Cefadroxil has been extensively studied in numerous clinical trials since its introduction, demonstrating efficacy and safety for its approved indications.
Lab Monitoring
- Monitor renal function (creatinine clearance, BUN) in patients with pre-existing renal impairment or during prolonged high-dose therapy.
- Periodic blood counts may be advisable during prolonged therapy.
Doctor Notes
- Assess renal function before initiating therapy, especially in elderly patients or those with known renal impairment.
- Counsel patients on completing the full course and potential for C. difficile-associated diarrhea if severe persistent diarrhea occurs.
Patient Guidelines
- Take the full prescribed course of antibiotics, even if you feel better, to prevent bacterial resistance.
- Do not share your medication with others.
- Inform your doctor if you experience severe diarrhea, rash, or any other unusual side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for the missed one.
Driving Precautions
Cefadroxil generally does not impair the ability to drive or operate machinery. However, if you experience dizziness or other central nervous system effects, avoid such activities.
Lifestyle Advice
- Maintain good personal hygiene to prevent the spread of infection.
- Stay well-hydrated during the course of treatment.
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