Oxigel
Generic Name
Oxetacaine + Aluminium Hydroxide + Magnesium Hydroxide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxigel 5 topical gel | ৳ 200.00 | N/A |
| oxigel 25 topical gel | ৳ 150.00 | N/A |
Description
Overview of the medicine
Oxigel is a combination medication containing oxetacaine, aluminium hydroxide, and magnesium hydroxide. It is used to relieve symptoms of hyperacidity, heartburn, indigestion, gastritis, and peptic ulcers by neutralizing stomach acid and providing a local anesthetic effect on the gastric mucosa to reduce pain.
Uses & Indications
Dosage
Adults
10-20 ml (2-4 teaspoonfuls) 3-4 times daily, 15 minutes before meals and at bedtime, or as directed by a physician.
Elderly
Similar to adult dosage. Use with caution in elderly patients with impaired renal function due to potential for magnesium accumulation.
Renal_impairment
Use with caution. Dosage adjustment may be required in severe renal impairment due to risk of hypermagnesemia.
How to Take
Shake the bottle well before use. Take orally, usually 15-30 minutes before meals and at bedtime. Do not exceed the recommended dose.
Mechanism of Action
Aluminium hydroxide and magnesium hydroxide act as antacids by neutralizing hydrochloric acid in the stomach, reducing acidity. Oxetacaine is a potent local anesthetic that provides rapid and prolonged pain relief by blocking nerve impulses in the gastric mucosa.
Pharmacokinetics
Onset
Rapid onset of action (within minutes) for both antacid and local anesthetic effects.
Excretion
Aluminium and magnesium are primarily excreted in feces. Minimally absorbed oxetacaine and its metabolites are excreted via kidneys.
Half life
Not significantly determined for the antacid components due to minimal absorption. Oxetacaine's systemic half-life is short if any absorption occurs.
Absorption
Aluminium and magnesium hydroxides are minimally absorbed from the gastrointestinal tract. Oxetacaine is also minimally absorbed orally, leading to local action with low systemic exposure.
Metabolism
Antacids are not metabolized. Minimally absorbed oxetacaine undergoes hepatic metabolism if it enters systemic circulation.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Severe renal impairment.
- Patients with appendicitis or intestinal obstruction.
Drug Interactions
Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH. Administer at least 2 hours apart.
Tetracyclines, Fluoroquinolones, Iron salts, Digoxin
Reduced absorption due to chelation or altered gastric pH. Administer at least 2 hours apart.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include constipation, diarrhea, nausea, vomiting, and in severe cases with renal impairment, hypermagnesemia (muscle weakness, hypotension, bradycardia, CNS depression). Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult a doctor before use. Magnesium may cause diarrhea in breastfed infants.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Severe renal impairment.
- Patients with appendicitis or intestinal obstruction.
Drug Interactions
Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH. Administer at least 2 hours apart.
Tetracyclines, Fluoroquinolones, Iron salts, Digoxin
Reduced absorption due to chelation or altered gastric pH. Administer at least 2 hours apart.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include constipation, diarrhea, nausea, vomiting, and in severe cases with renal impairment, hypermagnesemia (muscle weakness, hypotension, bradycardia, CNS depression). Treatment is symptomatic and supportive. Gastric lavage may be considered.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Consult a doctor before use. Magnesium may cause diarrhea in breastfed infants.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Pharmacies and drug stores
Approval Status
DGDA Approved in Bangladesh
Patent Status
Expired (Generic available)
Clinical Trials
Studies have shown the efficacy of combination antacids with local anesthetics in providing quick relief from symptoms of acidity and dyspepsia.
Lab Monitoring
- For prolonged use or in patients with renal impairment, periodic monitoring of serum magnesium and phosphate levels is recommended.
Doctor Notes
- Advise patients on appropriate lifestyle and dietary modifications alongside medication.
- Caution patients about potential drug interactions, especially with antibiotics and antifungals.
- Monitor for signs of electrolyte imbalance in patients with pre-existing renal conditions or prolonged use.
Patient Guidelines
- Shake the bottle well before each use.
- Do not exceed the recommended dose.
- Consult your doctor if symptoms persist after 7 days of use.
- Avoid taking other medications within 2 hours of taking Oxigel.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Oxigel is not known to affect the ability to drive or operate machinery. However, if you experience any side effects that could impair your ability, avoid such activities.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, or acidic foods.
- Eat smaller, more frequent meals.
- Elevate your head while sleeping to reduce nighttime heartburn.
- Reduce stress and avoid smoking and excessive alcohol consumption.
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Global Brand Names
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