Oxofyline
Generic Name
Oxofylline
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxofyline 100 mg syrup | ৳ 100.00 | N/A |
Description
Overview of the medicine
Oxofylline is a bronchodilator used to treat respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It helps relax the muscles in the airways, making breathing easier.
Uses & Indications
Dosage
Adults
100-200 mg (1-2 spoonfuls of syrup) 2-3 times daily, as directed by physician.
Elderly
Lower doses may be required, with careful monitoring due to potential reduced hepatic and renal function.
Renal_impairment
Dose adjustment may be necessary. Consult physician.
How to Take
Take orally, with or without food. Maintain a consistent dosing schedule. Measure the syrup carefully with a measuring spoon or cup.
Mechanism of Action
Oxofylline is a xanthine derivative. Its exact mechanism of action is not fully understood but is believed to involve non-selective phosphodiesterase inhibition, leading to increased intracellular cyclic AMP (cAMP), which causes smooth muscle relaxation in the bronchi and pulmonary vasculature. It also acts as an adenosine receptor antagonist.
Pharmacokinetics
Onset
Within 30-60 minutes after oral administration.
Excretion
Primarily excreted by the kidneys as metabolites and unchanged drug.
Half life
Approximately 6-12 hours, varies with age and liver function.
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Oxofylline or other xanthine derivatives.
- Acute myocardial infarction.
- Active peptic ulcer disease.
Drug Interactions
Beta-blockers
May reduce the bronchodilator effect of Oxofylline.
Phenobarbital, Phenytoin, Rifampicin
May decrease Oxofylline levels, reducing efficacy.
Cimetidine, Erythromycin, Fluoroquinolones
May increase Oxofylline levels, leading to toxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, restlessness, insomnia, tremor, palpitations, and potentially seizures or cardiac arrhythmias. Treatment is symptomatic and supportive, including gastric lavage, activated charcoal, and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy only if the potential benefit justifies the potential risk to the fetus. Oxofylline is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Hypersensitivity to Oxofylline or other xanthine derivatives.
- Acute myocardial infarction.
- Active peptic ulcer disease.
Drug Interactions
Beta-blockers
May reduce the bronchodilator effect of Oxofylline.
Phenobarbital, Phenytoin, Rifampicin
May decrease Oxofylline levels, reducing efficacy.
Cimetidine, Erythromycin, Fluoroquinolones
May increase Oxofylline levels, leading to toxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, restlessness, insomnia, tremor, palpitations, and potentially seizures or cardiac arrhythmias. Treatment is symptomatic and supportive, including gastric lavage, activated charcoal, and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy only if the potential benefit justifies the potential risk to the fetus. Oxofylline is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (Generally available)
Patent Status
Off-patent
Clinical Trials
Oxofylline has undergone various clinical trials demonstrating its efficacy as a bronchodilator for obstructive airway diseases, showing similar efficacy to other xanthines with a potentially better tolerability profile for some patients.
Lab Monitoring
- Plasma Oxofylline levels should be monitored, especially during initiation of therapy or dosage adjustments.
- Liver and renal function tests for long-term therapy.
Doctor Notes
- Monitor plasma Oxofylline levels, especially in patients with liver impairment, elderly, or those on interacting medications.
- Counsel patients on potential drug and food interactions, particularly caffeine.
- Adjust dosage based on clinical response and tolerability, aiming for the lowest effective dose.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any unusual or severe side effects immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Oxofylline may cause dizziness or tremor in some individuals. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Avoid smoking as it can affect the drug's efficacy.
- Limit caffeine intake to reduce potential side effects.
- Maintain a healthy lifestyle with regular exercise and a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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