Oxofyline
Generic Name
Oxofylline
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxofyline 100 mg syrup | ৳ 100.00 | N/A |
Description
Overview of the medicine
Oxofylline is a bronchodilator used to treat respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It helps relax the muscles in the airways, making breathing easier.
Uses & Indications
Dosage
Adults
100-200 mg (1-2 spoonfuls of syrup) 2-3 times daily, as directed by physician.
Elderly
Lower doses may be required, with careful monitoring due to potential reduced hepatic and renal function.
Renal_impairment
Dose adjustment may be necessary. Consult physician.
How to Take
Take orally, with or without food. Maintain a consistent dosing schedule. Measure the syrup carefully with a measuring spoon or cup.
Mechanism of Action
Oxofylline is a xanthine derivative. Its exact mechanism of action is not fully understood but is believed to involve non-selective phosphodiesterase inhibition, leading to increased intracellular cyclic AMP (cAMP), which causes smooth muscle relaxation in the bronchi and pulmonary vasculature. It also acts as an adenosine receptor antagonist.
Pharmacokinetics
Onset
Within 30-60 minutes after oral administration.
Excretion
Primarily excreted by the kidneys as metabolites and unchanged drug.
Half life
Approximately 6-12 hours, varies with age and liver function.
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver.
Side Effects
Contraindications
- •Hypersensitivity to Oxofylline or other xanthine derivatives.
- •Acute myocardial infarction.
- •Active peptic ulcer disease.
Drug Interactions
Beta-blockers
May reduce the bronchodilator effect of Oxofylline.
Phenobarbital, Phenytoin, Rifampicin
May decrease Oxofylline levels, reducing efficacy.
Cimetidine, Erythromycin, Fluoroquinolones
May increase Oxofylline levels, leading to toxicity.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include severe nausea, vomiting, restlessness, insomnia, tremor, palpitations, and potentially seizures or cardiac arrhythmias. Treatment is symptomatic and supportive, including gastric lavage, activated charcoal, and monitoring vital signs.
Pregnancy & Lactation
Pregnancy Category C. Use with caution during pregnancy only if the potential benefit justifies the potential risk to the fetus. Oxofylline is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (Generally available)
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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