Oxofyline
Generic Name
Acebrophylline
Manufacturer
Generic Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxofyline 200 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Acebrophylline is a xanthine derivative with both bronchodilator and mucoregulating properties. It is used in the treatment of various respiratory disorders, particularly chronic obstructive pulmonary disease (COPD) and bronchial asthma, to relieve bronchospasm and clear mucus.
Uses & Indications
Dosage
Adults
1 tablet (200 mg) twice daily.
Elderly
Similar to adult dose, but with caution.
Renal_impairment
Dosage adjustment may be required.
How to Take
Administer orally with or without food. It is generally recommended to take it after meals to minimize gastrointestinal discomfort.
Mechanism of Action
Acebrophylline exerts bronchodilating action by inhibiting phosphodiesterase, leading to increased cAMP levels and relaxation of bronchial smooth muscles. Its mucolytic action is attributed to the activation of serous glands and reduction of mucus viscosity.
Pharmacokinetics
Onset
30 minutes to 1 hour.
Excretion
Primarily via urine.
Half life
Approximately 4-5 hours.
Absorption
Well absorbed orally.
Metabolism
Hepatic metabolism.
Side Effects
Contraindications
- •Hypersensitivity to acebrophylline, other xanthine derivatives, or any component of the formulation.
- •Acute myocardial infarction.
- •Hypotension.
- •Arrhythmias.
- •Severe hepatic or renal impairment.
Drug Interactions
Phenytoin
May decrease acebrophylline levels.
Cimetidine
May increase acebrophylline levels.
Erythromycin
May increase acebrophylline levels.
Beta-blockers
May antagonize bronchodilator effect.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms may include nausea, vomiting, abdominal pain, restlessness, tremors, seizures, and cardiac arrhythmias. Management is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Consult a doctor. Generally not recommended unless clearly necessary.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic
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Global Brand Names
International brand names for this medicine
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