Paincare
Generic Name
Paracetamol and Caffeine
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| paincare 375 mg tablet | ৳ 13.00 | ৳ 130.00 |
| paincare 500 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Paincare is a combination medicine containing Paracetamol and Caffeine, used for the relief of mild to moderate pain, fever, and migraine headaches. Paracetamol acts as an analgesic and antipyretic, while Caffeine enhances its pain-relieving effects and helps combat fatigue.
Uses & Indications
Dosage
Adults
1-2 tablets every 4-6 hours as needed. Maximum 8 tablets in 24 hours.
Elderly
Generally same as adults, but caution for underlying conditions.
Renal_impairment
Dose adjustment may be necessary in severe renal impairment. Consult physician.
How to Take
Oral administration with water, with or without food.
Mechanism of Action
Paracetamol inhibits prostaglandin synthesis in the central nervous system. Caffeine acts as a CNS stimulant, enhancing the analgesic effect of paracetamol and constricting cerebral blood vessels, which helps in migraine.
Pharmacokinetics
Onset
30-60 minutes
Excretion
Mainly renal excretion as metabolites.
Half life
2-4 hours for Paracetamol, 3-7 hours for Caffeine
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations reached within 30-60 minutes.
Metabolism
Primarily hepatic, conjugated with glucuronic acid and sulfate. Caffeine metabolized by CYP1A2.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or Caffeine
- Severe hepatic impairment
- Severe renal impairment
- Uncontrolled hypertension
- Anxiety disorders
Drug Interactions
Alcohol
Increased risk of hepatotoxicity
Warfarin
Enhanced anticoagulant effect
Oral contraceptives
May decrease caffeine clearance
Certain antidepressants
Risk of increased CNS stimulation
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, sweating, drowsiness, and liver damage (Paracetamol). Caffeine overdose can cause restlessness, tremor, palpitations, and insomnia. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine for Paracetamol toxicity.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to Paracetamol or Caffeine
- Severe hepatic impairment
- Severe renal impairment
- Uncontrolled hypertension
- Anxiety disorders
Drug Interactions
Alcohol
Increased risk of hepatotoxicity
Warfarin
Enhanced anticoagulant effect
Oral contraceptives
May decrease caffeine clearance
Certain antidepressants
Risk of increased CNS stimulation
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, sweating, drowsiness, and liver damage (Paracetamol). Caffeine overdose can cause restlessness, tremor, palpitations, and insomnia. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine for Paracetamol toxicity.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, supermarkets, general stores
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used. Specific trials for this combination focus on efficacy in various pain types.
Lab Monitoring
- Liver function tests (for long-term high dose use)
- Renal function tests
Doctor Notes
- Advise patients on maximum daily dose to prevent hepatotoxicity.
- Counsel on avoiding concomitant use with other paracetamol-containing products.
- Monitor for caffeine sensitivity in susceptible patients.
Patient Guidelines
- Do not exceed the recommended dose.
- Consult a doctor if symptoms persist for more than 3 days.
- Avoid other paracetamol-containing products.
- Limit caffeine intake from other sources.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally safe, but if dizziness or drowsiness occurs, avoid driving or operating machinery.
Lifestyle Advice
- Stay hydrated.
- Get adequate rest.
- Avoid triggers for headaches/migraines.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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