Pansec
Generic Name
Pantoprazole
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pansec 20 mg tablet | ৳ 6.00 | ৳ 84.00 |
Description
Overview of the medicine
Pansec 20 mg Tablet contains Pantoprazole, a proton pump inhibitor (PPI) used to treat conditions where the stomach produces too much acid, such as heartburn, acid reflux, ulcers, and GERD. It helps relieve symptoms and prevent damage to the esophagus and stomach.
Uses & Indications
Dosage
Adults
For GERD and Erosive Esophagitis: 40 mg once daily for up to 8 weeks. For maintenance, 20-40 mg daily. For H. pylori eradication: 40 mg twice daily in combination therapy. For Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
No specific dosage adjustment is typically required, but caution is advised, especially with hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment or those on hemodialysis.
How to Take
Take the tablet whole with a glass of water, typically once daily in the morning, at least 30 minutes before a meal. Do not crush, chew, or break the tablet.
Mechanism of Action
Pantoprazole works by irreversibly binding to the H+/K+-ATPase enzyme system (the 'proton pump') on the secretory surface of the gastric parietal cells. This action inhibits the final step in gastric acid production, thereby reducing both basal and stimulated acid secretion.
Pharmacokinetics
Onset
Acid secretion inhibition begins within 2.5 hours, with full effect usually achieved after 2-3 days of continuous dosing.
Excretion
Approximately 80% is excreted in the urine as metabolites, and the remainder (about 18%) is excreted in the feces via biliary secretion.
Half life
Approximately 1 hour, but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration. Peak plasma concentrations are reached in approximately 2-2.5 hours. Absolute bioavailability is about 77%.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4. Metabolites are pharmacologically inactive.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Co-administration with atazanavir or nelfinavir due to potential reduction in their plasma concentrations.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin, requiring monitoring of digoxin levels.
Warfarin
Increased INR and prothrombin time, leading to increased risk of bleeding. Close monitoring is recommended.
Methotrexate
Pantoprazole may increase serum levels of methotrexate, especially at high doses. Consider temporary withdrawal of pantoprazole.
Atazanavir/Nelfinavir
Reduced absorption and plasma levels of these antiretrovirals, potentially leading to loss of virologic response and resistance. Co-administration is contraindicated.
Ketoconazole/Itraconazole/Posaconazole
Reduced absorption of these pH-dependent drugs due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Experience with pantoprazole overdose is limited. Symptoms may include mild gastrointestinal disturbances. Treatment is symptomatic and supportive. Pantoprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Pantoprazole should be used during pregnancy only if clearly needed. It is excreted in human milk; caution should be exercised when administered to a nursing woman. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Co-administration with atazanavir or nelfinavir due to potential reduction in their plasma concentrations.
Drug Interactions
Digoxin
Increased systemic exposure to digoxin, requiring monitoring of digoxin levels.
Warfarin
Increased INR and prothrombin time, leading to increased risk of bleeding. Close monitoring is recommended.
Methotrexate
Pantoprazole may increase serum levels of methotrexate, especially at high doses. Consider temporary withdrawal of pantoprazole.
Atazanavir/Nelfinavir
Reduced absorption and plasma levels of these antiretrovirals, potentially leading to loss of virologic response and resistance. Co-administration is contraindicated.
Ketoconazole/Itraconazole/Posaconazole
Reduced absorption of these pH-dependent drugs due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Experience with pantoprazole overdose is limited. Symptoms may include mild gastrointestinal disturbances. Treatment is symptomatic and supportive. Pantoprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Pantoprazole should be used during pregnancy only if clearly needed. It is excreted in human milk; caution should be exercised when administered to a nursing woman. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, as indicated on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
Widely approved globally
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Pantoprazole has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of GERD, erosive esophagitis, H. pylori eradication, and other acid-related disorders. Studies have confirmed its superior acid suppression compared to some other PPIs and H2 blockers.
Lab Monitoring
- Magnesium levels (especially with prolonged use beyond 3 months, or with diuretics)
- Vitamin B12 levels (with prolonged use, as PPIs can impair absorption)
- INR/prothrombin time (if co-administered with warfarin)
Doctor Notes
- Before initiating pantoprazole, consider ruling out malignancy in patients with alarm symptoms (e.g., dysphagia, unexplained weight loss, recurrent vomiting, GI bleeding) as symptomatic response does not preclude the presence of gastric malignancy.
- Advise patients on the appropriate administration, emphasizing taking before food and not crushing/chewing the tablet.
- Educate patients about potential long-term risks and the importance of regular follow-up for prolonged therapy.
Patient Guidelines
- Take Pansec exactly as prescribed by your doctor.
- Do not crush, chew, or break the tablet. Swallow it whole.
- Take the medicine at least 30 minutes before your first meal of the day.
- Inform your doctor if your symptoms do not improve or worsen.
- Do not stop taking Pansec abruptly without consulting your doctor, as this may worsen symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pantoprazole may cause dizziness or visual disturbances in some patients. If affected, do not drive or operate machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger your acid reflux symptoms (e.g., spicy foods, fatty foods, caffeine, alcohol).
- Eat smaller, more frequent meals instead of large ones.
- Elevate the head of your bed to reduce nighttime reflux.
- Maintain a healthy weight.
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