Pansec
Generic Name
Pantoprazole (as Sodium Sesquihydrate)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pansec 40 mg tablet | ৳ 8.00 | ৳ 112.00 |
Description
Overview of the medicine
Pansec 40 mg Tablet contains Pantoprazole, which is a proton pump inhibitor (PPI) used to treat conditions where there is too much acid in the stomach. It works by reducing the amount of acid produced by the stomach.
Uses & Indications
Dosage
Adults
Typical dose is 40 mg once daily for 4-8 weeks, depending on the condition. For H. pylori eradication, 40 mg twice daily in combination therapy.
Elderly
No specific dose adjustment is generally required, but caution is advised.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take orally, typically once daily, at least 30-60 minutes before breakfast. Do not crush, chew, or split the tablet.
Mechanism of Action
Pantoprazole is a substituted benzimidazole that inhibits the H+/K+-ATPase (proton pump) in the parietal cells of the stomach. This irreversible inhibition reduces both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Acid suppression begins within 1 hour; full effect within 2.5 hours.
Excretion
Mainly excreted renally (approx. 71%) and a smaller portion fecally (approx. 18%).
Half life
Approximately 1 hour (terminal half-life), but the duration of action is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration; peak plasma concentrations reached in 2-2.5 hours.
Metabolism
Extensively metabolized in the liver via cytochrome P450 system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole, substituted benzimidazoles, or any component of the formulation.
Drug Interactions
Tacrolimus
May increase tacrolimus serum levels.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.
Methotrexate
May increase serum methotrexate levels, especially with high doses.
Atazanavir/Nelfinavir
Reduced absorption due to increased gastric pH.
Iron Salts, Ketoconazole, Itraconazole
Absorption may be decreased due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include lethargy, tremor, abdominal pain, somnolence, and tachycardia. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole, substituted benzimidazoles, or any component of the formulation.
Drug Interactions
Tacrolimus
May increase tacrolimus serum levels.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition.
Methotrexate
May increase serum methotrexate levels, especially with high doses.
Atazanavir/Nelfinavir
Reduced absorption due to increased gastric pH.
Iron Salts, Ketoconazole, Itraconazole
Absorption may be decreased due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include lethargy, tremor, abdominal pain, somnolence, and tachycardia. Treatment is supportive and symptomatic.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety in acid-related disorders.
Lab Monitoring
- Monitor magnesium levels, especially with long-term use (over 3 months).
- Consider monitoring liver function tests in patients with severe hepatic impairment.
Doctor Notes
- Advise patients on appropriate diet and lifestyle changes.
- Regularly assess the need for continued PPI therapy to avoid long-term risks.
- Consider tapering dose if discontinuing after prolonged use.
Patient Guidelines
- Take as directed by your doctor, usually before breakfast.
- Swallow the tablet whole; do not chew or crush it.
- Inform your doctor about all other medications you are taking.
- Report any persistent or worsening symptoms to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods and beverages (e.g., spicy foods, caffeine, alcohol).
- Maintain a healthy weight and avoid large meals before bedtime.
- Quit smoking if you smoke, as it can worsen acid reflux.
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Global Brand Names
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