Pansec
Generic Name
Pantoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pansec 40 mg injection | ৳ 90.30 | N/A |
Description
Overview of the medicine
Pantoprazole is a proton pump inhibitor (PPI) used to treat conditions where there is too much acid in the stomach. Pansec-40 mg Injection is an intravenous formulation primarily for patients who cannot take oral therapy.
Uses & Indications
Dosage
Adults
Typically 40 mg once daily, intravenously. In severe cases of Zollinger-Ellison Syndrome, up to 80 mg twice daily may be administered.
Elderly
No specific dosage adjustment is usually required, but use with caution due to potential decreased liver function.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. For severe impairment, monitor for adverse effects.
How to Take
Administer intravenously over at least 2 minutes, or as an infusion over 15 minutes. It must be reconstituted with the provided solvent (e.g., 10 ml of 0.9% NaCl) immediately before use. Do not mix with other drugs.
Mechanism of Action
Pantoprazole is a substituted benzimidazole that inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby suppressing gastric acid secretion. This leads to an increase in gastric pH and reduction in acid-related symptoms.
Pharmacokinetics
Onset
Within 15-30 minutes after IV administration.
Excretion
Mainly renal (approx. 80%) and biliary/fecal (approx. 18%).
Half life
Approximately 1 hour (terminal half-life), but its duration of action for acid suppression is much longer (up to 24 hours).
Absorption
Rapidly absorbed after oral administration; for intravenous administration, it bypasses absorption challenges and has 100% bioavailability.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Clopidogrel
May reduce the antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
May increase methotrexate levels, especially with high doses, potentially leading to toxicity.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of these drugs due to increased gastric pH.
Atazanavir, Nelfinavir (and other antiretrovirals)
Reduced absorption of these drugs due to pantoprazole's effect on gastric pH, potentially leading to loss of virologic response.
Storage
Store below 25°C, protected from light and moisture. Do not freeze. Keep out of reach of children. Reconstituted solution stability is very limited.
Overdose
Symptoms may include drowsiness, tachycardia, nausea, headache. Treatment is symptomatic and supportive. Pantoprazole is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation; consider potential risks versus benefits.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Clopidogrel
May reduce the antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
May increase methotrexate levels, especially with high doses, potentially leading to toxicity.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of these drugs due to increased gastric pH.
Atazanavir, Nelfinavir (and other antiretrovirals)
Reduced absorption of these drugs due to pantoprazole's effect on gastric pH, potentially leading to loss of virologic response.
Storage
Store below 25°C, protected from light and moisture. Do not freeze. Keep out of reach of children. Reconstituted solution stability is very limited.
Overdose
Symptoms may include drowsiness, tachycardia, nausea, headache. Treatment is symptomatic and supportive. Pantoprazole is not effectively removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation; consider potential risks versus benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from the date of manufacture, as indicated on the packaging. Reconstituted solution must be used immediately.
Availability
Hospitals, pharmacies
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, patent expired for pantoprazole
WHO Essential Medicine
YesClinical Trials
Pantoprazole has undergone extensive clinical trials demonstrating its efficacy and safety for various acid-related disorders. Studies support its use for rapid and sustained gastric acid suppression in both acute and chronic conditions.
Lab Monitoring
- Magnesium levels (for prolonged therapy >3 months)
- Liver function tests (LFTs) if liver impairment is present or suspected.
- Chromogranin A (CgA) levels may be affected, requiring temporary cessation before testing.
Doctor Notes
- This IV formulation is intended for short-term use in patients unable to take oral pantoprazole. Switch to oral therapy as soon as clinically appropriate.
- Monitor patients on prolonged therapy (especially >3 months) for hypomagnesemia. Consider periodic bone density screening for high-risk patients.
- Pantoprazole may mask symptoms of gastric malignancy; endoscopy should be considered in patients with alarm symptoms or chronic recurrence.
- Adjust concomitant medications that rely on gastric pH for absorption.
Patient Guidelines
- Inform your doctor about all existing medical conditions and medications you are taking.
- Report any severe or persistent side effects immediately to your healthcare provider.
- Do not stop treatment abruptly without consulting a doctor, even if symptoms improve.
- This IV formulation is typically for short-term use; your doctor will advise when to switch to oral therapy.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or visual disturbances. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid spicy or fatty foods, caffeine, alcohol, and smoking to help manage acid reflux symptoms.
- Maintain a healthy weight and elevate the head of the bed if experiencing nocturnal reflux.
- Engage in stress-reducing activities.
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