Pantodac
Generic Name
Pantoprazole
Manufacturer
Zydus Cadila
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pantodac 20 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Pantoprazole is a proton pump inhibitor (PPI) used to treat conditions where there is too much acid in the stomach. It works by reducing the amount of acid produced in the stomach.
Uses & Indications
Dosage
Adults
GERD: 40 mg once daily for up to 8 weeks. Maintenance: 20-40 mg daily. Erosive Esophagitis: 40 mg once daily for up to 8 weeks. Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted based on patient response.
Elderly
Generally no dosage adjustment required, but use with caution due to potential for reduced hepatic function.
Renal_impairment
No dosage adjustment required.
How to Take
Take orally, preferably in the morning, at least 30 minutes before a meal. Do not crush, chew, or split the tablet.
Mechanism of Action
Pantoprazole irreversibly binds to the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, inhibiting the final step in gastric acid secretion.
Pharmacokinetics
Onset
Within 2.5 hours
Excretion
Mainly through renal excretion (approx. 80%) and biliary/fecal excretion (approx. 20%).
Half life
Approximately 1 hour (terminal half-life), but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 2-2.5 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Known hypersensitivity to pantoprazole or any component of the formulation
- Known hypersensitivity to substituted benzimidazoles (e.g., other PPIs)
Drug Interactions
Warfarin
Increased INR and prothrombin time; monitor closely.
Clopidogrel
Potential for reduced antiplatelet effect, though clinical significance debated; use with caution.
Methotrexate
Increased and prolonged serum levels of methotrexate, especially with high doses; consider temporary withdrawal of PPI.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption due to altered gastric pH; avoid co-administration.
Storage
Store at room temperature (below 30°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms are generally mild and include lethargy, confusion, tremor, palpitations. No specific antidote. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in human milk; use with caution in breastfeeding mothers, consider stopping breastfeeding or discontinuing the drug.
Side Effects
Contraindications
- Known hypersensitivity to pantoprazole or any component of the formulation
- Known hypersensitivity to substituted benzimidazoles (e.g., other PPIs)
Drug Interactions
Warfarin
Increased INR and prothrombin time; monitor closely.
Clopidogrel
Potential for reduced antiplatelet effect, though clinical significance debated; use with caution.
Methotrexate
Increased and prolonged serum levels of methotrexate, especially with high doses; consider temporary withdrawal of PPI.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption due to altered gastric pH; avoid co-administration.
Storage
Store at room temperature (below 30°C), away from moisture and direct light. Keep out of reach of children.
Overdose
Symptoms are generally mild and include lethargy, confusion, tremor, palpitations. No specific antidote. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in human milk; use with caution in breastfeeding mothers, consider stopping breastfeeding or discontinuing the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials demonstrating efficacy and safety for acid-related disorders.
Lab Monitoring
- Magnesium levels (with prolonged use)
- Vitamin B12 levels (with prolonged use)
- Chromogranin A (CgA) levels (may increase and interfere with neuroendocrine tumor diagnosis)
Doctor Notes
- Advise patients on lifestyle modifications.
- Consider discontinuing PPIs if long-term use is not strictly indicated.
- Educate patients on potential long-term risks with prolonged use.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty, acidic foods).
- Elevate the head of your bed if experiencing nighttime reflux.
- Avoid lying down immediately after meals.
- Quit smoking and reduce alcohol intake.
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Global Brand Names
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