Pantodac
Generic Name
Pantoprazole
Manufacturer
Sun Pharmaceutical Industries Ltd.
Country
India
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pantodac 40 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Pantodac-40-mg-tablet contains pantoprazole, a proton pump inhibitor (PPI) used to reduce stomach acid production, treating conditions like GERD, erosive esophagitis, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
40 mg once daily for 4-8 weeks, depending on indication. For Zollinger-Ellison Syndrome, dosage may be higher and adjusted based on acid output.
Elderly
No specific dose adjustment is usually required, but caution is advised in elderly patients with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment or those on hemodialysis.
How to Take
Take orally, swallow the tablet whole with water, preferably in the morning before a meal. Do not crush, chew, or break the tablet.
Mechanism of Action
Pantoprazole irreversibly inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby blocking the final step of acid secretion and reducing gastric acid levels.
Pharmacokinetics
Onset
Acid suppression begins within 2-3 hours, but full therapeutic effect may take several days.
Excretion
Approximately 80% is excreted renally as metabolites, and the remainder is excreted in feces via biliary secretion.
Half life
Terminal elimination half-life is about 1 hour, but the duration of acid suppression is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 77%. Peak plasma concentrations are reached in about 2-2.5 hours.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 (CYP) enzyme system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Potential for increased INR and prothrombin time, requiring monitoring.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition by pantoprazole.
Methotrexate
Increased and prolonged elevation of methotrexate and/or its metabolite serum levels, potentially leading to toxicity.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of these drugs due to pantoprazole-induced increase in gastric pH.
HIV Antivirals (e.g., Atazanavir, Nelfinavir)
Reduced absorption and efficacy of these drugs due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for pantoprazole overdose. In case of overdose, treatment should be symptomatic and supportive. Pantoprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B (US), Category C (Australia). Use only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Pantoprazole is excreted in breast milk; caution is advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Potential for increased INR and prothrombin time, requiring monitoring.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to CYP2C19 inhibition by pantoprazole.
Methotrexate
Increased and prolonged elevation of methotrexate and/or its metabolite serum levels, potentially leading to toxicity.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of these drugs due to pantoprazole-induced increase in gastric pH.
HIV Antivirals (e.g., Atazanavir, Nelfinavir)
Reduced absorption and efficacy of these drugs due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
There is no specific antidote for pantoprazole overdose. In case of overdose, treatment should be symptomatic and supportive. Pantoprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B (US), Category C (Australia). Use only if clearly needed and the potential benefit outweighs the potential risk to the fetus. Pantoprazole is excreted in breast milk; caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date, depending on specific formulation and packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved (DGDA, FDA equivalent in other countries)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Pantoprazole has undergone extensive clinical trials demonstrating its efficacy and safety for various acid-related disorders. Ongoing studies continue to explore its long-term effects and specific patient populations.
Lab Monitoring
- Serum magnesium levels (especially in patients on long-term therapy or with concomitant diuretic use)
- Liver function tests (in patients with hepatic impairment)
Doctor Notes
- Consider the lowest effective dose for the shortest duration necessary.
- Periodically assess the need for continued PPI therapy.
- Monitor for potential long-term side effects, especially hypomagnesemia and bone health.
- Educate patients on lifestyle modifications for acid reflux management.
Patient Guidelines
- Take Pantodac-40-mg-tablet exactly as prescribed by your doctor.
- Swallow the tablet whole with water; do not chew, crush, or break it.
- Take it preferably in the morning before your first meal for optimal acid suppression.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Pantoprazole is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness or visual disturbances occur, patients should avoid such activities.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, acidic foods, caffeine, and alcohol.
- Eat smaller, more frequent meals and avoid eating close to bedtime.
- Elevate the head of your bed to help reduce nighttime reflux symptoms.
- Maintain a healthy weight and quit smoking if applicable.
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