Powercef
Generic Name
Ceftriaxone 1 gm Injection
Manufacturer
Renata Limited (example)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| powercef 1 gm injection | ৳ 187.00 | N/A |
Description
Overview of the medicine
Ceftriaxone is a potent, broad-spectrum antibiotic used to treat a variety of serious bacterial infections. It belongs to the cephalosporin class of antibiotics.
Uses & Indications
Dosage
Adults
Usual adult dose is 1-2 grams once daily or in two divided doses depending on the type and severity of infection. Maximum daily dose is 4 grams.
Elderly
No specific dosage adjustment is required in elderly patients with normal renal and hepatic function. In severe impairment, dose adjustment may be necessary.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. For severe renal impairment (creatinine clearance <10 mL/min), dosage should not exceed 2 gm daily. Hemodialysis and peritoneal dialysis do not significantly remove ceftriaxone; no supplementary dose is needed.
How to Take
Powercef 1 gm Injection is administered either intravenously (IV) as a slow injection over 2-4 minutes or as an infusion over 30 minutes, or intramuscularly (IM) deep into a large muscle mass. The choice of route depends on the infection site and severity.
Mechanism of Action
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and bacterial death.
Pharmacokinetics
Onset
Rapid (IV); within 2-3 hours (IM)
Excretion
Excreted unchanged by the kidneys (approximately 35-65%) and biliary/fecal route (approximately 35-65%).
Half life
6-9 hours (prolonged in neonates and elderly)
Absorption
Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration. Peak plasma concentrations reached within 2-3 hours (IM) and immediately (IV).
Metabolism
Approximately 33-67% is metabolized in the liver to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, any other cephalosporin, or to any of the excipients.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems).
- Premature neonates up to 41 weeks corrected gestational age.
- Full-term neonates (up to 28 days of age) with hyperbilirubinemia, jaundice, or acidosis, or those receiving calcium-containing IV solutions.
Drug Interactions
Aminoglycosides
Synergistic effect against some bacteria, but monitor renal function due to potential for increased nephrotoxicity.
Calcium-containing solutions
Formation of precipitates in vivo, especially in neonates, can lead to serious adverse events. Do not administer simultaneously.
Diuretics (e.g., Furosemide)
High doses of furosemide may increase the risk of nephrotoxicity with ceftriaxone.
Oral Anticoagulants (e.g., Warfarin)
Increased risk of bleeding due to potential interference with Vitamin K synthesis. Close monitoring of INR is recommended.
Storage
Store the powder vial below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be given. Hemodialysis and peritoneal dialysis will not aid in the removal of ceftriaxone. Antidote is not available.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. It is excreted in breast milk in low concentrations; use with caution during lactation. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone, any other cephalosporin, or to any of the excipients.
- History of severe hypersensitivity reaction to any other type of beta-lactam antibacterial agent (e.g., penicillins, monobactams, carbapenems).
- Premature neonates up to 41 weeks corrected gestational age.
- Full-term neonates (up to 28 days of age) with hyperbilirubinemia, jaundice, or acidosis, or those receiving calcium-containing IV solutions.
Drug Interactions
Aminoglycosides
Synergistic effect against some bacteria, but monitor renal function due to potential for increased nephrotoxicity.
Calcium-containing solutions
Formation of precipitates in vivo, especially in neonates, can lead to serious adverse events. Do not administer simultaneously.
Diuretics (e.g., Furosemide)
High doses of furosemide may increase the risk of nephrotoxicity with ceftriaxone.
Oral Anticoagulants (e.g., Warfarin)
Increased risk of bleeding due to potential interference with Vitamin K synthesis. Close monitoring of INR is recommended.
Storage
Store the powder vial below 30°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be given. Hemodialysis and peritoneal dialysis will not aid in the removal of ceftriaxone. Antidote is not available.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. It is excreted in breast milk in low concentrations; use with caution during lactation. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years, as indicated on the packaging. Reconstituted solution must be used within specified timeframes (e.g., 6 hours at room temperature, 24 hours refrigerated).
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Generic available (Patent expired)
WHO Essential Medicine
YesClinical Trials
Ceftriaxone has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections since its introduction. Ongoing surveillance and post-marketing studies continue to monitor its profile.
Lab Monitoring
- Complete Blood Count (CBC) with differential, especially for prolonged therapy
- Liver function tests (AST, ALT, bilirubin)
- Renal function tests (BUN, creatinine)
- Coagulation parameters (PT/INR) in patients at risk of bleeding
Doctor Notes
- Always perform a thorough patient history regarding allergies, especially to beta-lactam antibiotics.
- Avoid co-administration with calcium-containing IV solutions, particularly in neonates.
- Monitor for signs of superinfection or Clostridium difficile-associated diarrhea during and after treatment.
- Adjust dosage in patients with severe hepatic and/or renal impairment.
Patient Guidelines
- Complete the full course of antibiotics as prescribed by your doctor, even if symptoms improve.
- Report any severe or persistent side effects to your doctor immediately.
- Do not self-medicate or share this medication with others.
- Ensure proper aseptic technique if administering at home (under professional guidance).
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.
Driving Precautions
Ceftriaxone may cause dizziness, lightheadedness, or tiredness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated by drinking plenty of fluids.
- Follow a balanced diet and get adequate rest to support recovery.
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