Powercef
Generic Name
Ceftriaxone
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| powercef 500 mg injection | ৳ 130.00 | N/A |
Description
Overview of the medicine
Powercef 500 mg Injection contains Ceftriaxone, a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is administered parenterally, primarily via intravenous or intramuscular routes.
Uses & Indications
Dosage
Adults
Usually 1-2 g administered once daily (or in two equally divided doses) IV or IM, depending on the severity of the infection. Max dose is 4 g/day. For uncomplicated gonorrhea, 500 mg IM single dose.
Elderly
No dosage adjustment is generally required unless there is severe renal or hepatic impairment.
Renal_impairment
No adjustment needed for mild to moderate impairment. For severe renal impairment (CrCl <10 mL/min), dosage should not exceed 2 g/day.
How to Take
For IV administration, dilute with appropriate solvent (e.g., Water for Injection, 0.9% NaCl) and infuse over 30 minutes. For IM administration, dilute with 1% Lidocaine solution and inject deep into a large muscle. Do not administer IV solutions containing calcium simultaneously.
Mechanism of Action
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bactericidal activity.
Pharmacokinetics
Onset
Rapid after IV/IM administration.
Excretion
Primarily via urine (about 40-65%) and bile (about 35-60%).
Half life
Approximately 5.8 to 8.7 hours (average 6-9 hours).
Absorption
Rapidly and completely absorbed after IM injection. Bioavailability is 100%.
Metabolism
Not extensively metabolized; about 35-65% excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone or any other cephalosporin antibiotic.
- History of severe hypersensitivity reaction to any other beta-lactam antibiotic (e.g., penicillins).
- Neonates with hyperbilirubinemia, especially premature infants.
- Neonates receiving calcium-containing IV solutions.
Drug Interactions
Loop diuretics
Increased risk of nephrotoxicity.
Aminoglycosides
Increased nephrotoxicity.
Calcium-containing solutions
Precipitation in neonates (contraindicated).
Oral anticoagulants (e.g., Warfarin)
Increased anticoagulant effect.
Storage
Store below 30°C. Protect from light. Do not freeze. Reconstituted solutions should be used immediately or within specified periods (e.g., 6 hours at room temperature, 24 hours refrigerated) depending on the solvent.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and central nervous system effects (e.g., convulsions at very high doses). Treatment is symptomatic and supportive. Hemodialysis and peritoneal dialysis are not effective for removing ceftriaxone.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Ceftriaxone is excreted in breast milk in low concentrations; caution should be exercised.
Side Effects
Contraindications
- Hypersensitivity to ceftriaxone or any other cephalosporin antibiotic.
- History of severe hypersensitivity reaction to any other beta-lactam antibiotic (e.g., penicillins).
- Neonates with hyperbilirubinemia, especially premature infants.
- Neonates receiving calcium-containing IV solutions.
Drug Interactions
Loop diuretics
Increased risk of nephrotoxicity.
Aminoglycosides
Increased nephrotoxicity.
Calcium-containing solutions
Precipitation in neonates (contraindicated).
Oral anticoagulants (e.g., Warfarin)
Increased anticoagulant effect.
Storage
Store below 30°C. Protect from light. Do not freeze. Reconstituted solutions should be used immediately or within specified periods (e.g., 6 hours at room temperature, 24 hours refrigerated) depending on the solvent.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and central nervous system effects (e.g., convulsions at very high doses). Treatment is symptomatic and supportive. Hemodialysis and peritoneal dialysis are not effective for removing ceftriaxone.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Ceftriaxone is excreted in breast milk in low concentrations; caution should be exercised.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date when stored correctly. Refer to the product packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available (patent expired)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established ceftriaxone's efficacy and safety in treating various bacterial infections. Ongoing research explores new indications and resistance patterns.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (creatinine, BUN)
- Liver function tests (AST, ALT)
- Coagulation parameters (PT/INR) in patients on anticoagulants or with vitamin K deficiency.
Doctor Notes
- Assess patient's allergy history, especially to beta-lactams, before administration.
- Monitor for signs of superinfection, especially C. difficile.
- Adjust dose in severe hepatic or renal impairment, or both.
- Never mix ceftriaxone with calcium-containing solutions in the same IV line, particularly in neonates.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve.
- Report any severe diarrhea, rash, or breathing difficulties immediately.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
Missed Dose Advice
If a dose is missed, administer it as soon as possible. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; caution is advised when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol during treatment if experiencing disulfiram-like reactions.
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