Pregabid
Generic Name
Pregabalin 25 mg Capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pregabid 25 mg capsule | ৳ 9.60 | ৳ 96.00 |
Description
Overview of the medicine
Pregabalin is an anticonvulsant and analgesic drug used to treat neuropathic pain, epilepsy, generalized anxiety disorder, and fibromyalgia.
Uses & Indications
Dosage
Adults
Initial dose 25-75 mg/day, usually divided into 2-3 doses. May be titrated up to a maximum of 300-600 mg/day depending on indication and patient response.
Elderly
Dose adjustment may be necessary in elderly patients with reduced renal function. Start with lower doses.
Renal_impairment
Dosage must be reduced significantly based on creatinine clearance. For CrCl 50-60 mL/min: 25-75 mg BID or TID; For CrCl 30-49 mL/min: 25-75 mg QD or BID; For CrCl <30 mL/min: 25-50 mg QD.
How to Take
Take orally, with or without food. Swallow the capsule whole with water.
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, thereby modulating the release of several excitatory neurotransmitters.
Pharmacokinetics
Onset
Within 1 week for neuropathic pain, varies for other conditions.
Excretion
Primarily renal excretion as unchanged drug.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations occur within 1.5 hours.
Metabolism
Negligible metabolism in humans; approximately 98% excreted unchanged in urine.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
May enhance CNS depressant effects leading to increased sedation, respiratory depression, and coma. Concomitant use should be with caution.
Thiazolidinedione Antidiabetic Agents (e.g., pioglitazone, rosiglitazone)
May increase the risk of weight gain and peripheral edema when co-administered with pregabalin.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and symptomatic; hemodialysis may be beneficial.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
May enhance CNS depressant effects leading to increased sedation, respiratory depression, and coma. Concomitant use should be with caution.
Thiazolidinedione Antidiabetic Agents (e.g., pioglitazone, rosiglitazone)
May increase the risk of weight gain and peripheral edema when co-administered with pregabalin.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and symptomatic; hemodialysis may be beneficial.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved and widely used
Patent Status
Generic available, original patent expired
Clinical Trials
Extensive clinical trials support its efficacy in neuropathic pain, epilepsy, GAD, and fibromyalgia. Ongoing research explores new indications.
Lab Monitoring
- Monitor renal function periodically, especially in elderly patients or those with pre-existing renal impairment.
Doctor Notes
- Initiate pregabalin therapy with a low dose and titrate gradually to achieve desired therapeutic effect while minimizing adverse reactions.
- Counsel patients on potential CNS depressant effects and the importance of not discontinuing abruptly.
- Monitor for signs of misuse or dependence, especially in patients with a history of substance abuse.
Patient Guidelines
- Do not stop taking Pregabid suddenly, as this may lead to withdrawal symptoms.
- Report any unusual mood changes, suicidal thoughts, or signs of allergic reactions (e.g., swelling of face, lips, tongue) to your doctor immediately.
- Avoid alcohol while taking this medicine.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Avoid driving or operating heavy machinery until you know how Pregabid affects you, as it may cause dizziness and somnolence.
- Maintain good hydration.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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