Pregabid
Generic Name
Pregabalin
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pregabid 75 mg capsule | ৳ 21.60 | ৳ 216.00 |
Description
Overview of the medicine
Pregabid 75 mg Capsule contains Pregabalin, an anticonvulsant and neuropathic pain agent. It is used to treat neuropathic pain (e.g., diabetic neuropathy, post-herpetic neuralgia), fibromyalgia, and as an adjunctive therapy for partial-onset seizures in adults.
Uses & Indications
Dosage
Adults
Initial dose is usually 75 mg twice daily or 50 mg three times daily (150 mg/day). May be increased to 150 mg twice daily or 100 mg three times daily (300 mg/day) within one week based on efficacy and tolerability. Maximum dose is usually 300 mg twice daily or 200 mg three times daily (600 mg/day).
Elderly
Dose adjustment may be required due to age-related decrease in renal function. Start with a lower dose and titrate cautiously.
Renal_impairment
Dose must be adjusted based on creatinine clearance. For CrCl 30-60 mL/min, maximum daily dose is 300 mg (divided). For CrCl 15-30 mL/min, maximum daily dose is 150 mg (divided). For CrCl <15 mL/min, maximum daily dose is 75 mg (divided).
How to Take
Take orally, with or without food. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This binding modulates the release of several excitatory neurotransmitters, thereby reducing neuronal hyperexcitability and pain signaling.
Pharmacokinetics
Onset
Pain relief may be seen within days to weeks; antiepileptic effects also observed over a similar timeframe. Anxiolytic effects may appear earlier.
Excretion
Excreted almost entirely unchanged in the urine (approximately 98% of the administered dose). Renal clearance is proportional to creatinine clearance.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed following oral administration, with peak plasma concentrations occurring within 1.5 hours. Oral bioavailability is ≥90% and is not affected by food.
Metabolism
Negligible systemic metabolism in humans. Less than 0.1% of the dose is excreted as metabolites.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
ACE Inhibitors
May increase the risk of angioedema when co-administered with pregabalin.
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
May enhance the central nervous system depressant effects of pregabalin, leading to increased sedation, dizziness, and respiratory depression. Use with caution.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and rarely, coma. Management is supportive and symptomatic. Hemodialysis may be effective in removing pregabalin from the plasma if clinically indicated.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; nursing is not recommended during treatment.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
ACE Inhibitors
May increase the risk of angioedema when co-administered with pregabalin.
CNS Depressants (e.g., opioids, benzodiazepines, alcohol)
May enhance the central nervous system depressant effects of pregabalin, leading to increased sedation, dizziness, and respiratory depression. Use with caution.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and rarely, coma. Management is supportive and symptomatic. Hemodialysis may be effective in removing pregabalin from the plasma if clinically indicated.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted in human milk; nursing is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
FDA approved (original drug, many generics follow)
Patent Status
Generics available, original patent expired
Clinical Trials
Extensively studied for its approved indications. Ongoing research explores its potential use in other conditions like generalized anxiety disorder, although not an approved indication for Pregabid 75 mg.
Lab Monitoring
- Monitor renal function (creatinine clearance) especially in elderly patients and those with pre-existing renal impairment.
- Periodically monitor for signs of edema and weight gain.
Doctor Notes
- Emphasize slow titration of dose to minimize CNS side effects.
- Counsel patients on the risk of suicidal thoughts and other neuropsychiatric adverse events.
- Adjust dose in renal impairment; consider lower starting doses in elderly patients.
Patient Guidelines
- Do not stop taking Pregabid abruptly, as this may lead to withdrawal symptoms. Your doctor will gradually reduce your dose.
- Report any unusual mood changes, depression, or suicidal thoughts to your doctor immediately.
- Avoid driving or operating heavy machinery until you know how Pregabid affects you, as it can cause dizziness and drowsiness.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pregabid may cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Exercise caution and avoid such activities until you are certain of its effects on you.
Lifestyle Advice
- Avoid alcohol consumption while taking Pregabid, as it can increase side effects like dizziness and drowsiness.
- Maintain adequate hydration.
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