Pregabid
Generic Name
Pregabalin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pregabid 50 mg capsule | ৳ 16.80 | ৳ 168.00 |
Description
Overview of the medicine
Pregabalin is an anticonvulsant and neuropathic pain medication. It is used to treat neuropathic pain, fibromyalgia, generalized anxiety disorder, and partial-onset seizures.
Uses & Indications
Dosage
Adults
Initial dose 50-150 mg/day, divided into 2-3 doses. Titrated up to 300-600 mg/day based on response and tolerability.
Elderly
Lower initial doses and slower titration recommended due to potential for decreased renal clearance.
Renal_impairment
Dosage adjustment required based on creatinine clearance.
How to Take
Take orally with or without food. Swallow the capsule whole with water. Do not crush or chew.
Mechanism of Action
Binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of several neurotransmitters (e.g., glutamate, norepinephrine, substance P).
Pharmacokinetics
Onset
Varies by indication, generally within days to a week for pain relief or anxiety reduction.
Excretion
Excreted primarily unchanged in the urine.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations typically within 1 hour.
Metabolism
Negligible hepatic metabolism, less than 0.1% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any excipients.
- Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Drug Interactions
ACE Inhibitors
May increase risk of angioedema.
CNS Depressants (e.g., opioids, benzodiazepines, ethanol)
May potentiate CNS depression (drowsiness, dizziness, decreased alertness).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, confusion, agitation, and restlessness. Treatment is supportive; hemodialysis can be effective.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any excipients.
- Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Drug Interactions
ACE Inhibitors
May increase risk of angioedema.
CNS Depressants (e.g., opioids, benzodiazepines, ethanol)
May potentiate CNS depression (drowsiness, dizziness, decreased alertness).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include somnolence, confusion, agitation, and restlessness. Treatment is supportive; hemodialysis can be effective.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as it is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies and hospitals
Approval Status
Approved by regulatory authorities worldwide, including FDA and DGDA.
Patent Status
Patent expired for generic Pregabalin
Clinical Trials
Extensively studied in clinical trials for its approved indications, demonstrating efficacy and safety profiles. Ongoing research explores new therapeutic applications.
Lab Monitoring
- Renal function (creatinine clearance) at baseline and periodically, especially in elderly and those with kidney impairment.
- Assess for signs of angioedema or suicidal ideation.
Doctor Notes
- Caution in patients with a history of substance abuse.
- Monitor for signs of angioedema, especially in patients also taking ACE inhibitors.
- Gradual tapering is crucial to prevent withdrawal symptoms.
Patient Guidelines
- Do not stop taking this medicine suddenly, as it can cause withdrawal symptoms. Always consult your doctor before discontinuing.
- Avoid alcohol while on this medication.
- Report any mood changes, suicidal thoughts, or unusual behavior to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness, somnolence, and blurred vision. Patients should be advised not to drive or operate complex machinery until they know how pregabalin affects them.
Lifestyle Advice
- Maintain a healthy lifestyle.
- Engage in stress-reducing activities like yoga or meditation.
- Ensure adequate sleep.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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