Prex-3
Generic Name
Prexacillin
Manufacturer
MediCare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prex 3 200 mg capsule | ৳ 35.00 | ৳ 245.00 |
Description
Overview of the medicine
Prex-3 200 mg Capsule is a broad-spectrum antibiotic containing Prexacillin, used to treat a variety of bacterial infections.
Uses & Indications
Dosage
Adults
200 mg to 500 mg every 8 hours, depending on the severity of the infection. Maximum 4g/day.
Elderly
No specific dose adjustment is usually required unless there is significant renal impairment. Use lower end of adult dose range.
Renal_impairment
Dose adjustment required. For creatinine clearance 10-30 mL/min, administer 200 mg every 12 hours. For <10 mL/min, administer 200 mg every 24 hours.
How to Take
Take orally, with or without food. It is recommended to take it with a glass of water.
Mechanism of Action
Prexacillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Within 30-60 minutes after oral administration.
Excretion
Mainly excreted via the kidneys (glomerular filtration and tubular secretion).
Half life
Approximately 1-1.5 hours in adults with normal renal function.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 70-80%.
Metabolism
Minimal hepatic metabolism; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to Prexacillin or any other penicillin antibiotic.
- Known history of severe allergic reactions to other beta-lactam antibiotics (e.g., cephalosporins).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of Warfarin; monitor INR.
Probenecid
Increases and prolongs Prexacillin blood levels.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and rarely, convulsions. Treatment is symptomatic and supportive. Hemodialysis may be useful in cases of severe overdose with renal impairment.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy. Excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to Prexacillin or any other penicillin antibiotic.
- Known history of severe allergic reactions to other beta-lactam antibiotics (e.g., cephalosporins).
Drug Interactions
Warfarin
May enhance the anticoagulant effect of Warfarin; monitor INR.
Probenecid
Increases and prolongs Prexacillin blood levels.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise additional contraceptive methods.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, and rarely, convulsions. Treatment is symptomatic and supportive. Hemodialysis may be useful in cases of severe overdose with renal impairment.
Pregnancy & Lactation
Pregnancy Category B. Generally considered safe during pregnancy. Excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Prexacillin has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections.
Lab Monitoring
- Renal function (for prolonged therapy or in patients with pre-existing renal impairment)
- Liver function tests (periodically during prolonged therapy)
Doctor Notes
- Advise patients to complete the full course to minimize resistance.
- Consider renal function adjustment in elderly or renally impaired patients.
- Monitor for signs of allergic reactions, especially in patients with a history of penicillin allergy.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve.
- Do not share this medication with others.
- Inform your doctor if you experience any unusual side effects or allergic reactions.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Prex-3 is generally not expected to affect the ability to drive or operate machinery. However, if dizziness occurs, exercise caution.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid alcohol consumption during the course of treatment, as it may exacerbate side effects.
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