Prioxon
Generic Name
Ceftriaxone 1 gm Injection
Manufacturer
Specific manufacturer varies by region (e.g., Square Pharmaceuticals, Renata Limited, Incepta Pharmaceuticals in Bangladesh)
Country
Varies by specific manufacturer (e.g., Bangladesh for local brands)
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prioxon 1 gm injection | ৳ 300.00 | N/A |
Description
Overview of the medicine
Prioxon 1 gm Injection contains Ceftriaxone, a third-generation cephalosporin antibiotic, used to treat a wide range of bacterial infections. It works by preventing the growth of bacteria.
Uses & Indications
Dosage
Adults
Typically 1-2 gm once daily, IV or IM, depending on the severity and type of infection. In severe cases, dosage may be increased up to 4 gm daily.
Elderly
No specific dosage adjustment is generally required for elderly patients with normal renal and hepatic function. Dosage should be based on severity of infection and renal/hepatic status.
Renal_impairment
No dosage adjustment needed for mild to moderate renal impairment. For severe renal impairment (creatinine clearance < 10 mL/min), dosage should not exceed 2 gm daily. Monitor plasma concentrations in severe cases.
How to Take
For intravenous (IV) administration, dissolve in appropriate solvent (e.g., Sterile Water for Injection, 0.9% Sodium Chloride) and administer slowly over 30 minutes. For intramuscular (IM) administration, dissolve in Lidocaine HCl solution and inject deeply into a large muscle mass.
Mechanism of Action
Ceftriaxone inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs), which are enzymes responsible for peptidoglycan synthesis. This ultimately leads to cell lysis and bacterial death.
Pharmacokinetics
Onset
Within 30 minutes (IV), 1-2 hours (IM)
Excretion
Approximately 50-60% excreted unchanged in urine via glomerular filtration, and 40-50% excreted unchanged in bile/feces.
Half life
Approximately 5.8 to 8.7 hours (prolonged in neonates, elderly, and those with renal/hepatic impairment)
Absorption
Rapidly and completely absorbed after intramuscular (IM) injection. High bioavailability (approximately 100%) after IM or intravenous (IV) administration.
Metabolism
Minimal metabolism; primarily converted to inactive metabolites in the intestine by bacterial flora.
Side Effects
Contraindications
- •Hypersensitivity to ceftriaxone or any other cephalosporins.
- •Previous immediate and severe hypersensitivity reaction to penicillin or any other beta-lactam antibacterial agent.
- •Neonates with hyperbilirubinemia, especially premature neonates, because ceftriaxone can displace bilirubin from serum albumin binding sites, potentially leading to kernicterus.
- •Concomitant use with intravenous calcium-containing solutions in neonates.
Drug Interactions
Aminoglycosides
Synergistic effect against some Gram-negative bacteria, but do not mix in the same syringe.
Calcium-containing solutions
Concomitant use in neonates is contraindicated due to precipitation. In other age groups, administer sequentially with flushing.
Loop diuretics (e.g., Furosemide)
May increase nephrotoxicity, especially in patients with pre-existing renal impairment.
Oral anticoagulants (e.g., Warfarin)
Increased INR/prothrombin time; monitor coagulation parameters.
Storage
Store unreconstituted powder below 30°C, protected from light and moisture. Reconstituted solutions should be stored at room temperature for 6 hours or refrigerated for 24 hours.
Overdose
In case of overdose, symptoms may include nausea, vomiting, and diarrhea. Treatment is primarily symptomatic and supportive. Hemodialysis and peritoneal dialysis are not effective for removing ceftriaxone.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. Ceftriaxone is excreted in breast milk in low concentrations; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored as per recommendations (unreconstituted). Reconstituted solution has a shorter shelf life.
Availability
Available in pharmacies, hospitals, and clinics
Approval Status
Approved by regulatory authorities worldwide (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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