Prioxon
Generic Name
Meropenem
Manufacturer
Reputable Pharmaceutical Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prioxon 500 mg injection | ৳ 200.00 | N/A |
Description
Overview of the medicine
Prioxon 500 mg Injection contains Meropenem, a broad-spectrum carbapenem antibiotic used to treat a wide variety of serious bacterial infections, including those affecting the skin, abdomen, brain, and lungs.
Uses & Indications
Dosage
Adults
Typically 500 mg to 1 g intravenously every 8 hours, depending on the severity and type of infection. For meningitis, 1 g every 8 hours.
Elderly
No specific dosage adjustment needed for elderly patients with normal renal function. Dosage should be adjusted based on renal function.
Renal_impairment
Dosage reduction is required for patients with creatinine clearance less than 51 mL/min. For CrCl 26-50 mL/min, 500 mg every 12 hours. For CrCl 10-25 mL/min, 500 mg every 24 hours. For CrCl <10 mL/min, 500 mg every 24 hours (after dialysis on dialysis days).
How to Take
Administered by intravenous infusion over 15 to 30 minutes, or by intravenous bolus injection over 3 to 5 minutes.
Mechanism of Action
Meropenem is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death.
Pharmacokinetics
Onset
Rapid onset of action, typically within minutes after IV infusion.
Excretion
Approximately 70% of the administered dose is excreted unchanged in the urine within 12 hours. Renal excretion is mainly via glomerular filtration and tubular secretion.
Half life
Approximately 1 hour in adults with normal renal function.
Absorption
Rapid and complete absorption after intravenous administration. Bioavailability is 100%.
Metabolism
Primarily metabolized by hydrolysis of the beta-lactam ring to an open-ring metabolite, which is microbiologically inactive. Not significantly metabolized by the liver.
Side Effects
Contraindications
- Known hypersensitivity to meropenem, any other carbapenems, or any component of the formulation.
- Severe hypersensitivity reactions (e.g., anaphylaxis, severe skin reactions) to any other beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Increases the plasma concentration and prolongs the half-life of meropenem by inhibiting its renal excretion. Co-administration is not recommended.
Valproic Acid
Concomitant use with meropenem may decrease valproic acid serum concentrations to subtherapeutic levels, leading to loss of seizure control. Avoid concomitant use; consider alternative antibiotics.
Oral Anticoagulants
Concomitant use with antibiotics, including carbapenems, may enhance the anticoagulant effects, increasing the risk of bleeding. Monitor INR.
Storage
Store dry powder vials at controlled room temperature (20-25°C) or as specified by the manufacturer. Protect from light. Do not freeze.
Overdose
In case of overdose, supportive treatment is recommended. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Meropenem is excreted in human milk; use with caution during lactation.
Side Effects
Contraindications
- Known hypersensitivity to meropenem, any other carbapenems, or any component of the formulation.
- Severe hypersensitivity reactions (e.g., anaphylaxis, severe skin reactions) to any other beta-lactam antibacterial agent (e.g., penicillins, cephalosporins).
Drug Interactions
Probenecid
Increases the plasma concentration and prolongs the half-life of meropenem by inhibiting its renal excretion. Co-administration is not recommended.
Valproic Acid
Concomitant use with meropenem may decrease valproic acid serum concentrations to subtherapeutic levels, leading to loss of seizure control. Avoid concomitant use; consider alternative antibiotics.
Oral Anticoagulants
Concomitant use with antibiotics, including carbapenems, may enhance the anticoagulant effects, increasing the risk of bleeding. Monitor INR.
Storage
Store dry powder vials at controlled room temperature (20-25°C) or as specified by the manufacturer. Protect from light. Do not freeze.
Overdose
In case of overdose, supportive treatment is recommended. Meropenem can be removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Meropenem is excreted in human milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years for dry powder vials when stored as recommended. Reconstituted solution has a shorter shelf life (e.g., 1-8 hours depending on diluent and temperature).
Availability
Hospitals, pharmacies
Approval Status
Approved by regulatory bodies globally (e.g., FDA, EMA, DGDA)
Patent Status
Generics available; original patent expired
WHO Essential Medicine
YesClinical Trials
Meropenem has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections. Ongoing post-marketing surveillance continues to monitor its use.
Lab Monitoring
- Regular monitoring of renal function (creatinine clearance, serum creatinine) in patients with pre-existing renal impairment.
- Monitor complete blood count (CBC) during prolonged therapy.
- Monitor liver function tests (LFTs) periodically.
Doctor Notes
- Empiric use should be guided by local epidemiology and susceptibility patterns.
- Consider therapeutic drug monitoring in critically ill patients or those with altered pharmacokinetics (e.g., renal impairment, sepsis).
- Patients with a history of penicillin or cephalosporin allergy should be carefully assessed for potential cross-reactivity.
Patient Guidelines
- Inform your doctor if you have a history of allergies, especially to antibiotics.
- Complete the full course of treatment as prescribed, even if symptoms improve, to prevent recurrence and resistance.
- Report any unusual side effects, especially severe diarrhea, rash, or seizure activity, immediately.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or seizures. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain good hygiene to prevent further infections.
- Stay hydrated by drinking plenty of fluids, unless medically advised otherwise.
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