Progut
Generic Name
Rabeprazole Sodium
Manufacturer
Beximco Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| progut 20 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Progut 20 mg tablet contains Rabeprazole Sodium, which belongs to a class of drugs called Proton Pump Inhibitors (PPIs). It reduces the amount of acid produced in the stomach, helping to treat and prevent acid-related conditions.
Uses & Indications
Dosage
Adults
Typical dose is 20 mg once daily. For GERD, usually for 4-8 weeks. For duodenal ulcer, 20 mg once daily for 4 weeks. For gastric ulcer, 20 mg once daily for 6 weeks. For H. pylori eradication, 20 mg twice daily with antibiotics for 7 days.
Elderly
No dosage adjustment is generally required.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Take the tablet whole with a glass of water. Do not chew or crush. It is usually taken before a meal, preferably in the morning.
Mechanism of Action
Rabeprazole acts as a proton pump inhibitor, irreversibly blocking the H+/K+-ATPase enzyme system at the secretory surface of the gastric parietal cells. This action inhibits the final step in gastric acid secretion, leading to a sustained decrease in gastric acidity.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour.
Excretion
Approximately 90% of the drug is excreted in the urine as metabolites, with the remaining 10% excreted in feces.
Half life
Plasma elimination half-life is approximately 1-2 hours.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring in approximately 2-3.5 hours. Bioavailability is about 52% due to first-pass metabolism.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes CYP2C19 and CYP3A4. Its metabolites are inactive.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Pregnancy and lactation (unless clearly necessary and benefit outweighs risk).
Drug Interactions
Digoxin
Increased digoxin absorption due to increased gastric pH.
Warfarin
Increased INR and prothrombin time. Monitor closely.
Clopidogrel
Potential for reduced antiplatelet effect of clopidogrel.
Atazanavir, Nelfinavir
Reduced plasma levels of these antiretrovirals; avoid co-administration.
Ketoconazole, Itraconazole
Reduced absorption of these drugs due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with overdose is limited. Symptoms may include lethargy, headache, nausea, vomiting, and diarrhea. Treatment should be symptomatic and supportive. Rabeprazole is not dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate human studies. Use during pregnancy only if clearly needed. It is not known if rabeprazole is excreted in human milk, so caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to rabeprazole, substituted benzimidazoles, or any component of the formulation.
- Pregnancy and lactation (unless clearly necessary and benefit outweighs risk).
Drug Interactions
Digoxin
Increased digoxin absorption due to increased gastric pH.
Warfarin
Increased INR and prothrombin time. Monitor closely.
Clopidogrel
Potential for reduced antiplatelet effect of clopidogrel.
Atazanavir, Nelfinavir
Reduced plasma levels of these antiretrovirals; avoid co-administration.
Ketoconazole, Itraconazole
Reduced absorption of these drugs due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with overdose is limited. Symptoms may include lethargy, headache, nausea, vomiting, and diarrhea. Treatment should be symptomatic and supportive. Rabeprazole is not dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate human studies. Use during pregnancy only if clearly needed. It is not known if rabeprazole is excreted in human milk, so caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on the manufacturer.
Availability
Available in pharmacies nationwide
Approval Status
FDA/DGDA approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Rabeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders, including GERD, peptic ulcers, and H. pylori eradication. Trials show rapid symptom relief and high healing rates.
Lab Monitoring
- Magnesium levels (especially with prolonged use or with other drugs that can cause hypomagnesemia)
- Liver function tests (if clinically indicated)
- Vitamin B12 levels (with prolonged use, >3 years)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary to achieve treatment goals.
- Re-evaluate the need for continued PPI therapy periodically, especially for long-term use.
- Counsel patients on potential long-term risks, including fracture, C. difficile infection, and hypomagnesemia.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not chew, crush, or break the tablet; swallow it whole.
- Inform your doctor about all other medications you are taking.
- Seek medical advice if symptoms do not improve or worsen.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Rabeprazole may cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods and drinks such as spicy foods, fatty foods, caffeine, and alcohol.
- Maintain a healthy weight and avoid large meals, especially close to bedtime.
- Elevate the head of your bed for GERD symptoms.
- Quit smoking as it can worsen acid reflux.
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