Progut
Generic Name
Esomeprazole 40 mg
Manufacturer
Square Pharmaceuticals PLC.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| progut 40 mg capsule | ৳ 11.00 | ৳ 110.00 |
Description
Overview of the medicine
Progut 40 mg Capsule contains Esomeprazole, a proton pump inhibitor that reduces the amount of acid produced in the stomach. It is used to treat conditions like heartburn, acid reflux, and stomach ulcers.
Uses & Indications
Dosage
Adults
Usually 20 mg or 40 mg once daily, taken at least one hour before a meal. Duration varies based on indication (e.g., 4-8 weeks for GERD).
Elderly
No specific dosage adjustment is generally required for elderly patients, but caution is advised in severe hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take the capsule orally, usually once daily, at least one hour before a meal. Swallow the capsule whole with water; do not crush, chew, or open it.
Mechanism of Action
Esomeprazole irreversibly inhibits the H+/K+-ATPase (proton pump) in the gastric parietal cells, thereby blocking the final step of acid production and leading to prolonged reduction of gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour of oral administration.
Excretion
Approximately 80% is excreted in the urine as metabolites, and the remaining 20% in the feces.
Half life
Approximately 1-1.5 hours.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 60% after a single 40 mg dose, increasing to 89% with repeated once-daily dosing.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19.
Methotrexate
May increase and prolong serum levels of methotrexate and/or its metabolite.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals due to decreased gastric acidity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Experience with esomeprazole overdose is limited. Symptoms observed in cases of overdose have been generally mild and reversible, including gastrointestinal disturbances and fatigue. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Esomeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Warfarin
Increased INR and prothrombin time have been reported, requiring monitoring.
Clopidogrel
Esomeprazole may reduce the antiplatelet effect of clopidogrel by inhibiting CYP2C19.
Methotrexate
May increase and prolong serum levels of methotrexate and/or its metabolite.
Atazanavir/Nelfinavir
Reduced plasma concentrations of these antiretrovirals due to decreased gastric acidity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Experience with esomeprazole overdose is limited. Symptoms observed in cases of overdose have been generally mild and reversible, including gastrointestinal disturbances and fatigue. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Esomeprazole is excreted in human milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Off-patent (generics available)
WHO Essential Medicine
YesClinical Trials
Esomeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in various acid-related disorders. Ongoing research continues to explore its use and long-term effects.
Lab Monitoring
- Monitor magnesium levels periodically in patients expected to be on prolonged treatment or who take PPIs with other drugs (e.g., diuretics) that may cause hypomagnesemia.
- Consider liver function tests in patients with severe hepatic impairment.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary to achieve the desired therapeutic effect.
- Consider testing for H. pylori infection in patients with recurrent symptoms before initiating long-term PPI therapy.
- Counsel patients on potential long-term risks with PPI use and the importance of adherence to lifestyle modifications.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Swallow the capsule whole; do not crush, chew, or open it.
- Take at least one hour before a meal.
- Inform your doctor if symptoms do not improve or worsen.
- Avoid discontinuing the medication suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medicine may cause dizziness, somnolence, or blurred vision. If you experience these symptoms, avoid driving or operating machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger heartburn (e.g., spicy foods, fatty foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed to reduce night-time reflux.
- Maintain a healthy weight.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Progut Brand
Other medicines available under the same brand name
