Pyrica
Generic Name
Pregabalin 50 mg capsule
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pyrica 50 mg capsule | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Pyrica 50 mg capsule contains Pregabalin, an anticonvulsant and neuropathic pain agent. It is used to treat neuropathic pain, fibromyalgia, and as adjunctive therapy for partial onset seizures in adults.
Uses & Indications
Dosage
Adults
Initial dose: 50 mg three times daily (TID). May be increased to 100 mg TID after 1 week. Maximum recommended dose is 600 mg/day.
Elderly
Dose adjustment may be necessary due to potential reduced renal function. Start with lower doses.
Renal_impairment
Significant dose reduction required based on creatinine clearance.
How to Take
Take orally with or without food. Swallow capsules whole with water.
Mechanism of Action
Pregabalin binds with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, thereby modulating the release of several neurotransmitters, including glutamate, norepinephrine, and substance P. This reduces neuronal excitability.
Pharmacokinetics
Onset
Pain relief usually within a week; full effect might take longer.
Excretion
Primarily excreted unchanged in the urine.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations typically occur within 1.5 hours.
Metabolism
Negligible metabolism in humans; excreted largely unchanged.
Side Effects
Contraindications
- •Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
Thiazolidinedione antidiabetic agents
Potential for increased peripheral edema and weight gain.
CNS depressants (e.g., opioids, benzodiazepines, alcohol)
Increased risk of CNS depression (somnolence, respiratory depression).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, agitation, and rarely coma. Treatment is supportive; hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Category C in pregnancy (animal studies show adverse effects, but no adequate human studies). Use only if potential benefit justifies potential risk. Excreted in breast milk; avoid if possible or monitor infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months, depending on specific manufacturer and formulation.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Patent expired, generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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