Ranzith
Generic Name
Azithromycin 200 mg/5 mL Suspension
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ranzith 200 mg suspension | ৳ 85.26 | N/A |
Description
Overview of the medicine
Azithromycin is a macrolide antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
500 mg once daily for 3 days or 500 mg on day 1, then 250 mg on days 2-5.
Elderly
Similar to adult dosage, no specific adjustment needed unless severe renal/hepatic impairment.
Renal_impairment
No dosage adjustment needed for mild to moderate impairment. Use with caution in severe impairment.
How to Take
Oral suspension can be taken with or without food. Shake well before use.
Mechanism of Action
Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit.
Pharmacokinetics
Onset
Variable, typically within 2-3 hours for peak plasma concentration.
Excretion
Primarily excreted unchanged in bile; minor renal excretion.
Half life
2-4 days (terminal half-life).
Absorption
Rapidly absorbed, bioavailability approximately 37%.
Metabolism
Extensively metabolized in the liver, primarily by demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin or any macrolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased digoxin levels.
Antacids
Decreased peak plasma concentrations of azithromycin.
Warfarin
Increased anticoagulant effect.
Nelfinavir
Increased azithromycin concentration.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms: Nausea, vomiting, diarrhea, reversible hearing loss. Management: Symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution.
Side Effects
Contraindications
- Hypersensitivity to azithromycin or any macrolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased digoxin levels.
Antacids
Decreased peak plasma concentrations of azithromycin.
Warfarin
Increased anticoagulant effect.
Nelfinavir
Increased azithromycin concentration.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms: Nausea, vomiting, diarrhea, reversible hearing loss. Management: Symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous trials support its efficacy in various infections, including respiratory, skin, and sexually transmitted infections.
Lab Monitoring
- Liver function tests: If hepatic dysfunction suspected.
- Renal function tests: In patients with severe renal impairment.
- ECG: In patients at risk for QT prolongation.
Doctor Notes
- Counsel patients on the importance of completing the full course of treatment to prevent resistance.
- Be aware of potential for QT prolongation in susceptible patients, especially those with pre-existing cardiac conditions or on other QT-prolonging drugs.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Shake the suspension well before each use.
- Do not stop medication early without consulting your doctor.
Missed Dose Advice
Take the missed dose as soon as remembered. If it's almost time for the next dose, skip the missed dose.
Driving Precautions
May cause dizziness; avoid driving or operating machinery if affected.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol if experiencing gastrointestinal side effects.
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International brand names for this medicine. Click a brand to search for detailed information.
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