Ranzith
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ranzith 250 mg capsule | ৳ 27.00 | ৳ 162.00 |
Description
Overview of the medicine
Ranzith 250 mg capsule contains Azithromycin, a macrolide antibiotic used to treat a wide range of bacterial infections including respiratory tract, skin, and sexually transmitted infections.
Uses & Indications
Dosage
Adults
For most infections, 500 mg once daily for 3 days, or 500 mg as a single dose on day 1 followed by 250 mg once daily for 4 days. For uncomplicated Chlamydia, a single 1 g dose.
Elderly
No specific dosage adjustment is recommended for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment is necessary for mild to moderate renal impairment (creatinine clearance > 10 mL/min). Exercise caution in severe renal impairment.
How to Take
Take orally, with or without food. To minimize gastrointestinal side effects, it may be taken with food. Do not chew or crush the capsule.
Mechanism of Action
Azithromycin works by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis and preventing bacterial growth.
Pharmacokinetics
Onset
Peak plasma concentrations in 2-3 hours.
Excretion
Primarily excreted unchanged in bile; a small amount (approximately 6%) is excreted in urine.
Half life
Terminal elimination half-life is 2-4 days due to extensive tissue distribution and slow release.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%. Peak plasma concentrations are reached in 2-3 hours.
Metabolism
Primarily metabolized in the liver, with significant first-pass metabolism, into inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Azithromycin, Erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior Azithromycin use
Drug Interactions
Digoxin
Increased Digoxin levels; monitor Digoxin levels.
Antacids
Reduced peak plasma concentrations of Azithromycin; take Azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased Azithromycin concentrations.
Ergot alkaloids (e.g., Ergotamine)
Potential for acute ergot toxicity.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Gastric lavage and general supportive measures are indicated. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed after careful consideration of risks and benefits. Excreted in breast milk; caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Azithromycin, Erythromycin, or any macrolide or ketolide antibiotic
- History of cholestatic jaundice/hepatic dysfunction associated with prior Azithromycin use
Drug Interactions
Digoxin
Increased Digoxin levels; monitor Digoxin levels.
Antacids
Reduced peak plasma concentrations of Azithromycin; take Azithromycin at least 1 hour before or 2 hours after antacids.
Warfarin
Increased anticoagulant effect, monitor INR.
Nelfinavir
Increased Azithromycin concentrations.
Ergot alkaloids (e.g., Ergotamine)
Potential for acute ergot toxicity.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Gastric lavage and general supportive measures are indicated. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed after careful consideration of risks and benefits. Excreted in breast milk; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Azithromycin has been extensively studied in numerous clinical trials demonstrating its efficacy and safety across various bacterial infections, leading to its widespread use.
Lab Monitoring
- Liver function tests (in patients with pre-existing hepatic impairment or during prolonged treatment)
- Renal function tests (in patients with severe renal impairment)
- INR (if co-administered with warfarin)
- ECG (in patients at risk of QT prolongation, e.g., with cardiac arrhythmias)
Doctor Notes
- Advise patients to complete the full course of therapy to ensure eradication and prevent resistance.
- Counsel on potential gastrointestinal upset; taking with food may help.
- Be aware of QT prolongation risk, especially in patients with pre-existing cardiac conditions or those on other QT-prolonging drugs.
- Monitor for signs of C. difficile-associated diarrhea (CDAD) and allergic reactions.
Patient Guidelines
- Complete the full course of treatment, even if symptoms improve, to prevent recurrence and resistance.
- Do not share this medicine with others, as it is prescribed for your specific condition.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, you are taking.
- Report any severe or persistent side effects, especially severe diarrhea or allergic reactions, to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness or visual disturbances; advise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration throughout the treatment period.
- Avoid alcohol consumption if experiencing gastrointestinal upset or liver problems.
- Practice good hygiene to prevent spread of infection.
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