Ranzith
Generic Name
Azithromycin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ranzith 500 mg tablet | ৳ 42.00 | ৳ 168.00 |
Description
Overview of the medicine
Ranzith 500 mg Tablet is a macrolide antibiotic used to treat various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases.
Uses & Indications
Dosage
Adults
For most infections, 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily for 4 days. For certain STIs, a single 1 g dose.
Elderly
No dosage adjustment needed for elderly patients with normal renal and hepatic function.
Renal_impairment
No dosage adjustment necessary for mild to moderate renal impairment (creatinine clearance > 10 mL/min). Use with caution in severe renal impairment.
How to Take
Administer orally, with or without food. For better absorption, it is often recommended to take it on an empty stomach (1 hour before or 2 hours after meals), but it can be taken with food to reduce gastrointestinal upset.
Mechanism of Action
Azithromycin works by binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis and consequently bacterial growth.
Pharmacokinetics
Onset
Typically within 2-3 hours.
Excretion
Mainly excreted unchanged in bile; a small amount is excreted via urine.
Half life
Terminal elimination half-life is 2-4 days (40-68 hours).
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.
Metabolism
Partially metabolized in the liver, primarily by N-demethylation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels. Monitor digoxin levels.
Warfarin
Increased anticoagulant effect. Monitor INR.
Nelfinavir
Increased azithromycin serum concentrations. Monitor for azithromycin side effects.
Antacids containing aluminum or magnesium
May decrease peak serum levels of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are typically an exaggeration of known side effects: severe nausea, vomiting, diarrhea, and reversible hearing loss. Management includes symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
- History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.
Drug Interactions
Digoxin
Increased serum digoxin levels. Monitor digoxin levels.
Warfarin
Increased anticoagulant effect. Monitor INR.
Nelfinavir
Increased azithromycin serum concentrations. Monitor for azithromycin side effects.
Antacids containing aluminum or magnesium
May decrease peak serum levels of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are typically an exaggeration of known side effects: severe nausea, vomiting, diarrhea, and reversible hearing loss. Management includes symptomatic and supportive measures.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of azithromycin for its approved indications.
Lab Monitoring
- Liver function tests (especially in patients with pre-existing hepatic impairment)
- ECG monitoring (in patients with risk factors for QT prolongation)
Doctor Notes
- Advise patients to complete the full course of therapy to prevent resistance.
- Be aware of potential for QT prolongation, especially in patients with pre-existing cardiac conditions or on other QT-prolonging drugs.
- Monitor for signs of hepatic dysfunction.
Patient Guidelines
- Complete the full course of medication even if symptoms improve.
- Do not share this medication with others.
- Report any severe or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid alcohol consumption during treatment if it causes discomfort.
- Follow hygiene practices to prevent further infection spread.
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